Human FAAH ELISA Kit (V2LY-0626-LY4575)

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Tested Data
Datasheet
SDS
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Basic Information

Sensitivity
0.0095 ng/mL
Detection Range
0.02-4.5 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
63.1 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Fatty Acid Amide Hydrolase
Research Area
Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:9122178, PubMed:17015445, PubMed:19926788).

Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (PubMed:9122178, PubMed:17015445).

It can also catalyze the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol) (PubMed:21049984).

FAAH cooperates with PM20D1 in the hydrolysis of amino acid-conjugated fatty acids such as N-fatty acyl glycine and N-fatty acyl-L-serine, thereby acting as a physiological regulator of specific subsets of intracellular, but not of extracellular, N-fatty acyl amino acids (By similarity).
Biological Process
Arachidonic acid metabolic process Source: Reactome
Fatty acid catabolic process Source: UniProtKB
Monoacylglycerol catabolic process Source: UniProtKB
Cellular Location
Cytoskeleton; Endomembrane system. Seems to be attached to intracellular membranes and a portion of the cytoskeletal network.

Genovese, T., Duranti, A., D’Amico, R., Fusco, R., Impellizzeri, D., Peritore, A. F., ... & Cordaro, M. (2022). Fatty Acid Amide Hydrolase (FAAH) Inhibition Plays a Key Role in Counteracting Acute Lung Injury. International Journal of Molecular Sciences, 23(5), 2781.

Grieco, M., De Caris, M. G., Maggi, E., Armeli, F., Coccurello, R., Bisogno, T., ... & Businaro, R. (2021). Fatty acid amide hydrolase (FAAH) inhibition modulates amyloid-beta-induced microglia polarization. International Journal of Molecular Sciences, 22(14), 7711.

Rafiei, D., & Kolla, N. J. (2021). Elevated brain fatty acid amide hydrolase induces depressive-like phenotypes in rodent models: A review. International Journal of Molecular Sciences, 22(3), 1047.

Matheson, J., Zhou, X. M. M., Bourgault, Z., & Le Foll, B. (2021). Potential of fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL), and diacylglycerol lipase (DAGL) enzymes as targets for obesity treatment: A narrative review. Pharmaceuticals, 14(12), 1316.

Schmidt, M. E., Liebowitz, M. R., Stein, M. B., Grunfeld, J., Van Hove, I., Simmons, W. K., ... & Drevets, W. C. (2021). The effects of inhibition of fatty acid amide hydrolase (FAAH) by JNJ-42165279 in social anxiety disorder: a double-blind, randomized, placebo-controlled proof-of-concept study. Neuropsychopharmacology, 46(5), 1004-1010.

Chiurchiù, V., Scipioni, L., Arosio, B., Mari, D., Oddi, S., & Maccarrone, M. (2021). Anti-inflammatory effects of fatty acid amide hydrolase inhibition in monocytes/macrophages from alzheimer’s disease patients. Biomolecules, 11(4), 502.

Tripathi, R. K. P. (2020). A perspective review on fatty acid amide hydrolase (FAAH) inhibitors as potential therapeutic agents. European Journal of Medicinal Chemistry, 188, 111953.

Mayo, L. M., Asratian, A., Lindé, J., Morena, M., Haataja, R., Hammar, V., ... & Heilig, M. (2020). Elevated anandamide, enhanced recall of fear extinction, and attenuated stress responses following inhibition of fatty acid amide hydrolase: a randomized, controlled experimental medicine trial. Biological psychiatry, 87(6), 538-547.

Brunetti, L., Loiodice, F., Piemontese, L., Tortorella, P., & Laghezza, A. (2019). New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation: Miniperspective. Journal of Medicinal Chemistry, 62(24), 10995-11003.

Balsevich, G., Sticht, M., Bowles, N. P., Singh, A., Lee, T. T., Li, Z., ... & Hill, M. N. (2018). Role for fatty acid amide hydrolase (FAAH) in the leptin-mediated effects on feeding and energy balance. Proceedings of the National Academy of Sciences, 115(29), 7605-7610.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Rat Faah ELISA Kit (CAT#: V2LY-0626-LY2207)

FAAH Matched Antibody Pair (397) (CAT#: APMAB-397LY)

Antibody Pairs

FAAH Matched Antibody Pair (397) (CAT#: APMAB-397LY)

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Mouse Anti-FAAH Recombinant Antibody (CBXF-2785) (CAT#: V2LY-0825-LY1183)

Mouse Anti-FAAH Recombinant Antibody (5F9) (CAT#: CBMAB-A2790-LY)

Mouse Anti-FAAH Recombinant Antibody (CBXF-0218) (CAT#: V2LY-0825-LY1181)

FAAH Matched Antibody Pair (397) (CAT#: APMAB-397LY)

Rat Faah ELISA Kit (CAT#: V2LY-0626-LY2207)

Mouse Anti-FAAH Recombinant Antibody (CBXF-2221) (CAT#: V2LY-0825-LY1180)

Mouse Anti-FAAH Recombinant Antibody (CBXF-2784) (CAT#: V2LY-0825-LY1182)

Rabbit Anti-FAAH Recombinant Antibody (CBXF-2050) (CAT#: CBMAB-F2008-CQ)

Isotype control

For research use only. Not intended for any clinical use.

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