Mouse Agr2 ELISA Kit (V2LY-0626-LY2033)

Name: Mouse Agr2 ELISA Kit
SKU: V2LY-0626-LY2033
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.142 ng/mL

Detection Range

0.3-90 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Mouse

Assay Type

Sandwich

Reactivity

Mouse

Assay Time

1.5 h

Molecule Mass

19.9 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

Anterior Gradient 2, Protein Disulphide Isomerase Family Member

Function

Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion.

Biological Process

Digestive tract morphogenesis
Mucus secretion
Negative regulation of cell death
Positive regulation of cell-substrate adhesion
Positive regulation of developmental growth
Positive regulation of epidermal growth factor receptor signaling pathway
Positive regulation of gene expression
Positive regulation of IRE1-mediated unfolded protein response
Positive regulation of PERK-mediated unfolded protein response
Positive regulation of protein localization to plasma membrane

Cellular Location

Secreted; Endoplasmic reticulum

Wang, Y., Jia, M., Liang, C., Sheng, N., Wang, X., Wang, F., ... & Yuan, H. (2021). Anterior gradient 2 increases long-chain fatty acid uptake via stabilizing FABP1 and facilitates lipid accumulation. International journal of biological sciences, 17(3), 834.

Delom, F., Mohtar, M. A., Hupp, T., & Fessart, D. (2020). The anterior gradient-2 interactome. American Journal of Physiology-Cell Physiology, 318(1), C40-C47.

Moidu, N. A., Rahman, N. S. A., Syafruddin, S. E., Low, T. Y., & Mohtar, M. A. (2020). Secretion of pro-oncogenic AGR2 protein in cancer. Heliyon, 6(9), e05000.

Wang, D., Xu, Q., Yuan, Q., Jia, M., Niu, H., Liu, X., ... & Yuan, H. (2019). Proteasome inhibition boosts autophagic degradation of ubiquitinated-AGR2 and enhances the antitumor efficiency of bevacizumab. Oncogene, 38(18), 3458-3474.

Maurel, M., Obacz, J., Avril, T., Ding, Y. P., Papadodima, O., Treton, X., ... & Ogier‐Denis, E. (2019). Control of anterior GR adient 2 (AGR 2) dimerization links endoplasmic reticulum proteostasis to inflammation. EMBO molecular medicine, 11(6), e10120.

Tiemann, K., Garri, C., Lee, S. B., Malihi, P. D., Park, M., Alvarez, R. M., ... & Kani, K. (2019). Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis. Oncogene, 38(16), 3003-3018.

Zhang, Y., Xia, F., Zhang, F., Cui, Y., Wang, Q., Liu, H., & Wu, Y. (2019). miR-135b-5p enhances doxorubicin-sensitivity of breast cancer cells through targeting anterior gradient 2. Journal of Experimental & Clinical Cancer Research, 38(1), 1-13.

Li, J., Hu, J., Luo, Z., Zhou, C., Huang, L., Zhang, H., ... & Wang, Z. (2019). AGR2 is controlled by DNMT3a-centered signaling module and mediates tumor resistance to 5-Aza in colorectal cancer. Experimental cell research, 385(1), 111644.

Delom, F., Nazaraliyev, A., & Fessart, D. (2018). The role of protein disulphide isomerase AGR2 in the tumour niche. Biology of the Cell, 110(12), 271-282.

Zhu, Q., Mangukiya, H. B., Mashausi, D. S., Guo, H., Negi, H., Merugu, S. B., ... & Li, D. (2017). Anterior gradient 2 is induced in cutaneous wound and promotes wound healing through its adhesion domain. The FEBS journal, 284(17), 2856-2869.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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