AGR2
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression. [provided by RefSeq, Mar 2017]
Full Name
Anterior Gradient 2, Protein Disulphide Isomerase Family Member
Function
Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion.
Biological Process
Digestive tract morphogenesis
Mucus secretion
Negative regulation of cell death
Positive regulation of cell-substrate adhesion
Positive regulation of developmental growth
Positive regulation of epidermal growth factor receptor signaling pathway
Positive regulation of gene expression
Positive regulation of IRE1-mediated unfolded protein response
Positive regulation of PERK-mediated unfolded protein response
Positive regulation of protein localization to plasma membrane
Mucus secretion
Negative regulation of cell death
Positive regulation of cell-substrate adhesion
Positive regulation of developmental growth
Positive regulation of epidermal growth factor receptor signaling pathway
Positive regulation of gene expression
Positive regulation of IRE1-mediated unfolded protein response
Positive regulation of PERK-mediated unfolded protein response
Positive regulation of protein localization to plasma membrane
Cellular Location
Secreted; Endoplasmic reticulum
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Anti-AGR2 antibodies
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CompareTarget: AGR2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: V2-634170
Application*: IC, IH, IP, WB
Target: AGR2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: V2-611035
Application*: WB, E
Target: AGR2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: V2-611033
Application*: WB, E
Target: AGR2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: V2-180206
Application*: E, WB, IP
Target: AGR2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: V2-180204
Application*: WB, P, IF, F
Target: AGR2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: V2-180192
Application*: E, WB
Target: AGR2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: V2-180190
Application*: E, WB
Target: AGR2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Cattle, Dog, Horse, Mouse, Rat
Clone: V2-180188
Application*: P, IH, WB
Target: AGR2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Rat
Clone: V2-66359
Application*: IC, IH, IP, WB
Target: Agr2
Sensitivity: 0.142 ng/mL
Detection Range: 0.3-90 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: AGR2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4488
Application*: IH, F
Target: AGR2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4163
Application*: IC, F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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