AGR2

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression. [provided by RefSeq, Mar 2017]
Full Name
Anterior Gradient 2, Protein Disulphide Isomerase Family Member
Function
Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion.
Biological Process
Digestive tract morphogenesis
Mucus secretion
Negative regulation of cell death
Positive regulation of cell-substrate adhesion
Positive regulation of developmental growth
Positive regulation of epidermal growth factor receptor signaling pathway
Positive regulation of gene expression
Positive regulation of IRE1-mediated unfolded protein response
Positive regulation of PERK-mediated unfolded protein response
Positive regulation of protein localization to plasma membrane
Cellular Location
Secreted; Endoplasmic reticulum
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Anti-AGR2 antibodies

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Mouse Anti-AGR2 Recombinant Antibody (V2-634170) (CBMAB-AP204LY)

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Target: AGR2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: V2-634170
Application*: IC, IH, IP, WB
Datasheet SDS

Mouse Anti-AGR2 Recombinant Antibody (V2-611035) (CBMAB-A0188-LY)

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Target: AGR2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: V2-611035
Application*: WB, E
Datasheet SDS

Mouse Anti-AGR2 Recombinant Antibody (V2-611033) (CBMAB-A0186-LY)

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Target: AGR2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: V2-611033
Application*: WB, E
Datasheet SDS

Mouse Anti-AGR2 Recombinant Antibody (V2-180206) (CBMAB-A1630-YC)

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Target: AGR2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: V2-180206
Application*: E, WB, IP
Datasheet SDS

Rabbit Anti-AGR2 Recombinant Antibody (V2-180204) (CBMAB-A1628-YC)

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Target: AGR2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: V2-180204
Application*: WB, P, IF, F
Datasheet SDS

Mouse Anti-AGR2 Recombinant Antibody (V2-180192) (CBMAB-A1616-YC)

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Target: AGR2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: V2-180192
Application*: E, WB
Datasheet SDS

Mouse Anti-AGR2 Recombinant Antibody (V2-180190) (CBMAB-A1614-YC)

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Target: AGR2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: V2-180190
Application*: E, WB
Datasheet SDS

Mouse Anti-AGR2 Recombinant Antibody (V2-180188) (CBMAB-A1612-YC)

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Target: AGR2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Cattle, Dog, Horse, Mouse, Rat
Clone: V2-180188
Application*: P, IH, WB
Datasheet SDS

Mouse Anti-AGR2 Recombinant Antibody (V2-66359) (CBMAB-G0005-LY)

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Target: AGR2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Rat
Clone: V2-66359
Application*: IC, IH, IP, WB
Datasheet SDS

Mouse Anti-AGR2 Recombinant Antibody (CBT4488) (V2LY-0625-LY529)

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Target: AGR2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4488
Application*: IH, F
Datasheet SDS

Mouse Anti-AGR2 Recombinant Antibody (CBT4163) (V2LY-0625-LY528)

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Target: AGR2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4163
Application*: IC, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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