Human HAAO ELISA Kit (V2LY-0626-LY4297)

Name: Human HAAO ELISA Kit
SKU: V2LY-0626-LY4297
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.0098 ng/mL

Detection Range

0.02-4.5 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

32.6 kDa

Components

Pre-coated ELISA plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

3-hydroxyanthranilate 3,4-dioxygenase

Function

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.

Biological Process

de novo' NAD biosynthetic process from tryptophan Source: GO_Central
Anthranilate metabolic process Source: UniProtKB-UniRule
NAD biosynthetic process Source: UniProtKB
Neuron cellular homeostasis Source: UniProtKB
Quinolinate biosynthetic process Source: UniProtKB
Quinolinate metabolic process Source: GO_Central
Response to cadmium ion Source: UniProtKB
Response to zinc ion Source: UniProtKB
Tryptophan catabolic process Source: UniProtKB-UniRule

Cellular Location

Cytosol

Involvement in disease

Vertebral, cardiac, renal, and limb defects syndrome 1 (VCRL1):
An autosomal recessive congenital malformation syndrome characterized by vertebral segmentation abnormalities, congenital cardiac defects, renal defects, and distal mild limb defects.

Sanz, I., Altomare, A., Mondanelli, G., Protti, M., Valsecchi, V., Mercolini, L., ... & Regazzoni, L. (2022). Chromatographic measurement of 3-hydroxyanthranilate 3, 4-dioxygenase activity reveals that edaravone can mitigate the formation of quinolinic acid through a direct enzyme inhibition. Journal of Pharmaceutical and Biomedical Analysis, 219, 114948.

Wang, Y., Liu, K. F., Yang, Y., Davis, I., & Liu, A. (2020). Observing 3-hydroxyanthranilate-3, 4-dioxygenase in action through a crystalline lens. Proceedings of the National Academy of Sciences, 117(33), 19720-19730.

Yang, Y., Liu, F., & Liu, A. (2018). Adapting to oxygen: 3-Hydroxyanthrinilate 3, 4-dioxygenase employs loop dynamics to accommodate two substrates with disparate polarities. Journal of Biological Chemistry, 293(27), 10415-10424.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant HAAO protein, GST Tag (CAT#: V2LY-0526-LY4448)

Rat Recombinant HAAO protein, His Tag (CAT#: V2LY-0526-LY9409)

Related Products

Human Recombinant HAAO protein, GST Tag (CAT#: V2LY-0526-LY4448)

Rat Recombinant HAAO protein, His Tag (CAT#: V2LY-0526-LY9409)

Mouse Anti-HAAO Recombinant Antibody (CBFYH-0645) (CAT#: CBMAB-H0551-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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