Human Recombinant HAAO protein, GST Tag (V2LY-0526-LY4448)

Name: Human Recombinant HAAO protein, GST Tag
SKU: V2LY-0526-LY4448
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant HAAO protein, GST Tag consist of Amino Acid: 1-286 and predicts a molecular mass of 60.4 kDa.

Molecule Mass

60.4 kDa

Sequence

Amino Acid: 1-286

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥90% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Liquid

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

3-hydroxyanthranilate 3,4-dioxygenase

Function

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.

Biological Process

de novo' NAD biosynthetic process from tryptophan Source: GO_Central
Anthranilate metabolic process Source: UniProtKB-UniRule
NAD biosynthetic process Source: UniProtKB
Neuron cellular homeostasis Source: UniProtKB
Quinolinate biosynthetic process Source: UniProtKB
Quinolinate metabolic process Source: GO_Central
Response to cadmium ion Source: UniProtKB
Response to zinc ion Source: UniProtKB
Tryptophan catabolic process Source: UniProtKB-UniRule

Cellular Location

Cytosol

Involvement in disease

Vertebral, cardiac, renal, and limb defects syndrome 1 (VCRL1):
An autosomal recessive congenital malformation syndrome characterized by vertebral segmentation abnormalities, congenital cardiac defects, renal defects, and distal mild limb defects.

Sanz, I., Altomare, A., Mondanelli, G., Protti, M., Valsecchi, V., Mercolini, L., ... & Regazzoni, L. (2022). Chromatographic measurement of 3-hydroxyanthranilate 3, 4-dioxygenase activity reveals that edaravone can mitigate the formation of quinolinic acid through a direct enzyme inhibition. Journal of Pharmaceutical and Biomedical Analysis, 219, 114948.

Wang, Y., Liu, K. F., Yang, Y., Davis, I., & Liu, A. (2020). Observing 3-hydroxyanthranilate-3, 4-dioxygenase in action through a crystalline lens. Proceedings of the National Academy of Sciences, 117(33), 19720-19730.

Yang, Y., Liu, F., & Liu, A. (2018). Adapting to oxygen: 3-Hydroxyanthrinilate 3, 4-dioxygenase employs loop dynamics to accommodate two substrates with disparate polarities. Journal of Biological Chemistry, 293(27), 10415-10424.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Rat Recombinant HAAO protein, His Tag (CAT#: V2LY-0526-LY9409)

Human HAAO ELISA Kit (CAT#: V2LY-0626-LY4297)

Related Products

Mouse Anti-HAAO Recombinant Antibody (CBFYH-0645) (CAT#: CBMAB-H0551-FY)

Human HAAO ELISA Kit (CAT#: V2LY-0626-LY4297)

Rat Recombinant HAAO protein, His Tag (CAT#: V2LY-0526-LY9409)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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