Human IL18BP ELISA Kit (V2LY-0626-LY3421)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.0024 ng/mL
Detection Range
0.005-2 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
21.1 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Interleukin 18 Binding Protein
Function
Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response.
Biological Process
Cellular response to hydrogen peroxide Source: Ensembl
Cellular response to tumor necrosis factor Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
T-helper 1 type immune response Source: UniProtKB
Cellular Location
Secreted
Involvement in disease
Hepatitis, fulminant viral (FVH):
An autosomal recessive form of fulminant viral hepatitis, a disease that strikes otherwise healthy individuals during primary infection with common liver-tropic viruses. FVH is characterized by severe liver destruction in the absence of a preexisting liver disorder, leading to encephalopathy within 8 weeks of the onset of the first symptoms.
PTM
N- and O-glycosylated. O-glycosylated with core 1-like and core 2-like glycans. O-glycan heterogeneity at Ser-53: HexHexNAc (major) and Hex2HexNAc2 (minor). N-glycan heterogeneity at Asn-103: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major) and Hex6HexNAc5 (minor); N-glycan at Asn-147: dHex1Hex5HexNAc4.

Marino, L., Criniti, A., Guida, S., Bucci, T., Ballesio, L., Suppa, M., ... & Gandini, O. (2023). Interleukin 18 and IL-18 BP response to Sars-CoV-2 virus infection. Clinical and experimental medicine, 23(4), 1243-1250.

Yazıcı, Y. Y., Belkaya, S., & Timucin, E. (2023). A small non-interface surface epitope in human IL18 mediates the dynamics and self-assembly of IL18-IL18BP heterodimers. Computational and Structural Biotechnology Journal, 21, 3522-3531.

Jun, H. T., Witherden, D. A., Elliot, E. K., Chidester, C. M., Willen, M., Peguero, B. R., ... & King, D. J. (2023). Discovery and evaluation of an anti-IL18BP antibody to enhance anti-tumor immunity. Cancer Research, 83(7_Supplement), 1824-1824.

Nisthal, A., Lee, S. H., Bonzon, C., Love, R., Avery, K., Rashid, R., ... & Desjarlais, J. (2022). 1372 XmAb143, an engineered IL18 heterodimeric Fc-fusion, features improved stability, reduced potency, and insensitivity to IL18BP.

Li, X., Abrahams, C., Gakhal, A., Yang, J., Brar, K., Calarese, D., ... & Hallam, T. (2022). 1359 Half-life extended engineered IL18 variants that escape the negative regulation of IL18BP.

Nisthal, A., Lee, S. H., Bonzon, C., Love, R., Avery, K. N., Rashid, R., ... & Desjarlais, J. R. (2022). Engineered IL18 heterodimeric Fc-fusions featuring improved stability, reduced potency, and insensitivity to IL18BP. Cancer Research, 82(12_Supplement), 3515-3515.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human IL18BP ELISA Kit (2) (CAT#: V2LY-0626-LY4221)

Mouse Il18bp ELISA Kit (CAT#: V2LY-0626-LY5795)

Human Recombinant IL18BP protein, hFc Tag (CAT#: V2LY-0526-LY4790)

Human Recombinant IL18BP protein, His Tag (CAT#: V2LY-0526-LY4791)

Human Recombinant IL18BP protein, His Tag-1 (CAT#: V2LY-0526-LY4792)

Mouse Recombinant IL18BP protein, His Tag (CAT#: V2LY-0526-LY8498)

Mouse Recombinant IL18BP protein, His Tag-1 (CAT#: V2LY-0526-LY8499)

Related Products

Mouse Recombinant IL18BP protein, His Tag (CAT#: V2LY-0526-LY8498)

Mouse Anti-IL18BP Recombinant Antibody (A489) (CAT#: CBMAB-AP10856LY)

Mouse Anti-IL18BP Recombinant Antibody (MM0379-10G36) (CAT#: CBMAB-I0883-YY)

Mouse Il18bp ELISA Kit (CAT#: V2LY-0626-LY5795)

Mouse Anti-IL18BP Recombinant Antibody (CBYY-I1228) (CAT#: CBMAB-I2397-YY)

Human Recombinant IL18BP protein, hFc Tag (CAT#: V2LY-0526-LY4790)

Mouse Recombinant IL18BP protein, His Tag-1 (CAT#: V2LY-0526-LY8499)

Mouse Anti-IL18BP Recombinant Antibody (2A9) (CAT#: CBMAB-A4364-LY)

Rabbit Anti-IL18BP Recombinant Antibody (EP1088Y) (CAT#: CBMAB-I1253-YY)

Human Recombinant IL18BP protein, His Tag (CAT#: V2LY-0526-LY4791)

Isotype control

For research use only. Not intended for any clinical use.

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