Human Recombinant IL18BP protein, hFc Tag (V2LY-0526-LY4790)

Name: Human Recombinant IL18BP protein, hFc Tag
SKU: V2LY-0526-LY4790
Rating: 5 (1 reviews)

See all IL18BP antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

hFc Tag

Protein Construction

This product is Human Recombinant IL18BP protein, hFc Tag consist of Amino Acid: 1-192 and predicts a molecular mass of 44.4 kDa.

Molecule Mass

44.4 kDa

Sequence

Amino Acid: 1-192

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Interleukin 18 Binding Protein

Function

Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response.

Biological Process

Cellular response to hydrogen peroxide Source: Ensembl
Cellular response to tumor necrosis factor Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
T-helper 1 type immune response Source: UniProtKB

Cellular Location

Secreted

Involvement in disease

Hepatitis, fulminant viral (FVH):
An autosomal recessive form of fulminant viral hepatitis, a disease that strikes otherwise healthy individuals during primary infection with common liver-tropic viruses. FVH is characterized by severe liver destruction in the absence of a preexisting liver disorder, leading to encephalopathy within 8 weeks of the onset of the first symptoms.

PTM

N- and O-glycosylated. O-glycosylated with core 1-like and core 2-like glycans. O-glycan heterogeneity at Ser-53: HexHexNAc (major) and Hex2HexNAc2 (minor). N-glycan heterogeneity at Asn-103: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major) and Hex6HexNAc5 (minor); N-glycan at Asn-147: dHex1Hex5HexNAc4.

Marino, L., Criniti, A., Guida, S., Bucci, T., Ballesio, L., Suppa, M., ... & Gandini, O. (2023). Interleukin 18 and IL-18 BP response to Sars-CoV-2 virus infection. Clinical and experimental medicine, 23(4), 1243-1250.

Yazıcı, Y. Y., Belkaya, S., & Timucin, E. (2023). A small non-interface surface epitope in human IL18 mediates the dynamics and self-assembly of IL18-IL18BP heterodimers. Computational and Structural Biotechnology Journal, 21, 3522-3531.

Jun, H. T., Witherden, D. A., Elliot, E. K., Chidester, C. M., Willen, M., Peguero, B. R., ... & King, D. J. (2023). Discovery and evaluation of an anti-IL18BP antibody to enhance anti-tumor immunity. Cancer Research, 83(7_Supplement), 1824-1824.

Nisthal, A., Lee, S. H., Bonzon, C., Love, R., Avery, K., Rashid, R., ... & Desjarlais, J. (2022). 1372 XmAb143, an engineered IL18 heterodimeric Fc-fusion, features improved stability, reduced potency, and insensitivity to IL18BP.

Li, X., Abrahams, C., Gakhal, A., Yang, J., Brar, K., Calarese, D., ... & Hallam, T. (2022). 1359 Half-life extended engineered IL18 variants that escape the negative regulation of IL18BP.

Nisthal, A., Lee, S. H., Bonzon, C., Love, R., Avery, K. N., Rashid, R., ... & Desjarlais, J. R. (2022). Engineered IL18 heterodimeric Fc-fusions featuring improved stability, reduced potency, and insensitivity to IL18BP. Cancer Research, 82(12_Supplement), 3515-3515.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Human Recombinant IL18BP protein, hFc Tag?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human IL18BP ELISA Kit (CAT#: V2LY-0626-LY3421)

Human IL18BP ELISA Kit (2) (CAT#: V2LY-0626-LY4221)

Mouse Il18bp ELISA Kit (CAT#: V2LY-0626-LY5795)

Human Recombinant IL18BP protein, His Tag (CAT#: V2LY-0526-LY4791)

Human Recombinant IL18BP protein, His Tag-1 (CAT#: V2LY-0526-LY4792)

Mouse Recombinant IL18BP protein, His Tag (CAT#: V2LY-0526-LY8498)

Mouse Recombinant IL18BP protein, His Tag-1 (CAT#: V2LY-0526-LY8499)

Related Products

Human Recombinant IL18BP protein, His Tag (CAT#: V2LY-0526-LY4791)

Mouse Anti-IL18BP Recombinant Antibody (A489) (CAT#: CBMAB-AP10856LY)

Mouse Recombinant IL18BP protein, His Tag-1 (CAT#: V2LY-0526-LY8499)

Mouse Anti-IL18BP Recombinant Antibody (A487) (CAT#: CBMAB-AP3778LY)

Human Recombinant IL18BP protein, His Tag-1 (CAT#: V2LY-0526-LY4792)

Mouse Anti-IL18BP Recombinant Antibody (CB60A) (CAT#: CBMAB-CA060LY)

Mouse Anti-IL18BP Recombinant Antibody (CBYY-I1022) (CAT#: CBMAB-I2190-YY)

Mouse Recombinant IL18BP protein, His Tag (CAT#: V2LY-0526-LY8498)

Human IL18BP ELISA Kit (2) (CAT#: V2LY-0626-LY4221)

Rabbit Anti-IL18BP Recombinant Antibody (EP1088Y) (CAT#: CBMAB-I1253-YY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry