Mouse Recombinant IL18BP protein, His Tag-1 (V2LY-0526-LY8499)

Name: Mouse Recombinant IL18BP protein, His Tag-1
SKU: V2LY-0526-LY8499
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Mouse

Tag

His Tag

Protein Construction

This product is Mouse Recombinant IL18BP protein, His Tag consist of Amino Acid: 1-193 and predicts a molecular mass of 19.4 kDa.

Molecule Mass

19.4 kDa

Verified

HPLC

Sequence

Amino Acid: 1-193

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥90% as determined by SDS-PAGE. ≥90% as determined by SEC-HPLC.

Endotoxin

<0.5 EU/mg protein.

Format

Liquid

Buffer

PBS, NaCl, Trehalose, Mannitol, Tween80

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Interleukin 18 Binding Protein

Function

Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response.

Biological Process

Cellular response to hydrogen peroxide Source: Ensembl
Cellular response to tumor necrosis factor Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
T-helper 1 type immune response Source: UniProtKB

Cellular Location

Secreted

Involvement in disease

Hepatitis, fulminant viral (FVH):
An autosomal recessive form of fulminant viral hepatitis, a disease that strikes otherwise healthy individuals during primary infection with common liver-tropic viruses. FVH is characterized by severe liver destruction in the absence of a preexisting liver disorder, leading to encephalopathy within 8 weeks of the onset of the first symptoms.

PTM

N- and O-glycosylated. O-glycosylated with core 1-like and core 2-like glycans. O-glycan heterogeneity at Ser-53: HexHexNAc (major) and Hex2HexNAc2 (minor). N-glycan heterogeneity at Asn-103: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major) and Hex6HexNAc5 (minor); N-glycan at Asn-147: dHex1Hex5HexNAc4.

Marino, L., Criniti, A., Guida, S., Bucci, T., Ballesio, L., Suppa, M., ... & Gandini, O. (2023). Interleukin 18 and IL-18 BP response to Sars-CoV-2 virus infection. Clinical and experimental medicine, 23(4), 1243-1250.

Yazıcı, Y. Y., Belkaya, S., & Timucin, E. (2023). A small non-interface surface epitope in human IL18 mediates the dynamics and self-assembly of IL18-IL18BP heterodimers. Computational and Structural Biotechnology Journal, 21, 3522-3531.

Jun, H. T., Witherden, D. A., Elliot, E. K., Chidester, C. M., Willen, M., Peguero, B. R., ... & King, D. J. (2023). Discovery and evaluation of an anti-IL18BP antibody to enhance anti-tumor immunity. Cancer Research, 83(7_Supplement), 1824-1824.

Nisthal, A., Lee, S. H., Bonzon, C., Love, R., Avery, K., Rashid, R., ... & Desjarlais, J. (2022). 1372 XmAb143, an engineered IL18 heterodimeric Fc-fusion, features improved stability, reduced potency, and insensitivity to IL18BP.

Li, X., Abrahams, C., Gakhal, A., Yang, J., Brar, K., Calarese, D., ... & Hallam, T. (2022). 1359 Half-life extended engineered IL18 variants that escape the negative regulation of IL18BP.

Nisthal, A., Lee, S. H., Bonzon, C., Love, R., Avery, K. N., Rashid, R., ... & Desjarlais, J. R. (2022). Engineered IL18 heterodimeric Fc-fusions featuring improved stability, reduced potency, and insensitivity to IL18BP. Cancer Research, 82(12_Supplement), 3515-3515.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human IL18BP ELISA Kit (CAT#: V2LY-0626-LY3421)

Human IL18BP ELISA Kit (2) (CAT#: V2LY-0626-LY4221)

Mouse Il18bp ELISA Kit (CAT#: V2LY-0626-LY5795)

Human Recombinant IL18BP protein, hFc Tag (CAT#: V2LY-0526-LY4790)

Human Recombinant IL18BP protein, His Tag (CAT#: V2LY-0526-LY4791)

Human Recombinant IL18BP protein, His Tag-1 (CAT#: V2LY-0526-LY4792)

Mouse Recombinant IL18BP protein, His Tag (CAT#: V2LY-0526-LY8498)

Related Products

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12C2) (CAT#: V2LY-0725-LY321)

Human Recombinant IL18BP protein, His Tag-1 (CAT#: V2LY-0526-LY4792)

Mouse Anti-IL18BP Recombinant Antibody (A487) (CAT#: CBMAB-AP3778LY)

Mouse Anti-IL18BP Recombinant Antibody (5C7-D2-G4-B6) (CAT#: CBMAB-I1432-YY)

Human IL18BP ELISA Kit (CAT#: V2LY-0626-LY3421)

Mouse Anti-IL18BP Recombinant Antibody (2A9) (CAT#: CBMAB-A4364-LY)

Human Recombinant IL18BP protein, hFc Tag (CAT#: V2LY-0526-LY4790)

Mouse Anti-IL18BP Recombinant Antibody (A489) (CAT#: CBMAB-AP10856LY)

Mouse Il18bp ELISA Kit (CAT#: V2LY-0626-LY5795)

Mouse Anti-IL18BP Recombinant Antibody (CBYY-I1022) (CAT#: CBMAB-I2190-YY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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