IL18BP
The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Full Name
Interleukin 18 Binding Protein
Function
Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response.
Biological Process
Cellular response to hydrogen peroxide Source: Ensembl
Cellular response to tumor necrosis factor Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
T-helper 1 type immune response Source: UniProtKB
Cellular response to tumor necrosis factor Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
T-helper 1 type immune response Source: UniProtKB
Cellular Location
Secreted
Involvement in disease
Hepatitis, fulminant viral (FVH):
An autosomal recessive form of fulminant viral hepatitis, a disease that strikes otherwise healthy individuals during primary infection with common liver-tropic viruses. FVH is characterized by severe liver destruction in the absence of a preexisting liver disorder, leading to encephalopathy within 8 weeks of the onset of the first symptoms.
An autosomal recessive form of fulminant viral hepatitis, a disease that strikes otherwise healthy individuals during primary infection with common liver-tropic viruses. FVH is characterized by severe liver destruction in the absence of a preexisting liver disorder, leading to encephalopathy within 8 weeks of the onset of the first symptoms.
PTM
N- and O-glycosylated. O-glycosylated with core 1-like and core 2-like glycans. O-glycan heterogeneity at Ser-53: HexHexNAc (major) and Hex2HexNAc2 (minor). N-glycan heterogeneity at Asn-103: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major) and Hex6HexNAc5 (minor); N-glycan at Asn-147: dHex1Hex5HexNAc4.
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Anti-IL18BP antibodies
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CompareTarget: IL18BP
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-193
Tag: His Tag
Target: IL18BP
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-193
Tag: His Tag
Target: IL18BP
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-194
Tag: His Tag
Target: IL18BP
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-194
Tag: His Tag
Target: IL18BP
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-192
Tag: hFc Tag
Target: IL18BP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 12C2
Application*: E, WB
Target: IL18BP
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A490
Application*: ICC, IHC, IP, WB
Target: IL18BP
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A489
Application*: WB
Target: IL18BP
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A488
Application*: ELISA, WB
Target: IL18BP
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A487
Application*: WB
Target: IL18BP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CB60A
Application*: ELISA, WB
Target: IL18BP
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2A9
Application*: WB, E
Target: IL18BP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I1228
Application*: E, EC
Target: IL18BP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Hamster, Human
Clone: CBYY-I1022
Application*: siRNA, E, IF, WB
Target: IL18BP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 5C7-D2-G4-B6
Application*: WB
Target: IL18BP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat, Human
Clone: EP1088Y
Application*: WB, P, F
Target: IL18BP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MM0379-10G36
Application*: WB, BL, N
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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