Mouse Anti-IL18BP Recombinant Antibody (A488) (CBMAB-AP3776LY)

Name: Mouse Anti-IL18BP Recombinant Antibody (A488)
SKU: CBMAB-AP3776LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

A488

Application

ELISA, WB

Immunogen

Purified recombinant human IL18BP protein fragments expressed in E.coli.

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

Affinity purity

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Interleukin 18 Binding Protein

Introduction

The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

Entrez Gene ID

10068

UniProt ID

O95998

Alternative Names

Interleukin 18 Binding Protein

Function

CSB-MA222469

Biological Process

Cellular response to hydrogen peroxide Source: Ensembl
Cellular response to tumor necrosis factor Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
T-helper 1 type immune response Source: UniProtKB

Cellular Location

Secreted

Involvement in disease

Hepatitis, fulminant viral (FVH):
An autosomal recessive form of fulminant viral hepatitis, a disease that strikes otherwise healthy individuals during primary infection with common liver-tropic viruses. FVH is characterized by severe liver destruction in the absence of a preexisting liver disorder, leading to encephalopathy within 8 weeks of the onset of the first symptoms.

PTM

N- and O-glycosylated. O-glycosylated with core 1-like and core 2-like glycans. O-glycan heterogeneity at Ser-53: HexHexNAc (major) and Hex2HexNAc2 (minor). N-glycan heterogeneity at Asn-103: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major) and Hex6HexNAc5 (minor); N-glycan at Asn-147: dHex1Hex5HexNAc4.

Marino, L., Criniti, A., Guida, S., Bucci, T., Ballesio, L., Suppa, M., ... & Gandini, O. (2023). Interleukin 18 and IL-18 BP response to Sars-CoV-2 virus infection. Clinical and experimental medicine, 23(4), 1243-1250.

Yazıcı, Y. Y., Belkaya, S., & Timucin, E. (2023). A small non-interface surface epitope in human IL18 mediates the dynamics and self-assembly of IL18-IL18BP heterodimers. Computational and Structural Biotechnology Journal, 21, 3522-3531.

Jun, H. T., Witherden, D. A., Elliot, E. K., Chidester, C. M., Willen, M., Peguero, B. R., ... & King, D. J. (2023). Discovery and evaluation of an anti-IL18BP antibody to enhance anti-tumor immunity. Cancer Research, 83(7_Supplement), 1824-1824.

Nisthal, A., Lee, S. H., Bonzon, C., Love, R., Avery, K., Rashid, R., ... & Desjarlais, J. (2022). 1372 XmAb143, an engineered IL18 heterodimeric Fc-fusion, features improved stability, reduced potency, and insensitivity to IL18BP.

Li, X., Abrahams, C., Gakhal, A., Yang, J., Brar, K., Calarese, D., ... & Hallam, T. (2022). 1359 Half-life extended engineered IL18 variants that escape the negative regulation of IL18BP.

Nisthal, A., Lee, S. H., Bonzon, C., Love, R., Avery, K. N., Rashid, R., ... & Desjarlais, J. R. (2022). Engineered IL18 heterodimeric Fc-fusions featuring improved stability, reduced potency, and insensitivity to IL18BP. Cancer Research, 82(12_Supplement), 3515-3515.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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