Human Recombinant BRD2, Active protein, His Tag (V2LY-0526-LY2407)

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Basic Information

Expressed Host
E. coli
Protein Species
Human
Tag
His Tag
Protein Construction
This product is Human Recombinant BRD2, Active protein, His Tag consist of Amino Acid: 339-459 and predicts a molecular mass of 15 kDa.
Molecule Mass
15 kDa
Sequence
Amino Acid: 339-459
Species
Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
Batch dependent.
Endotoxin
Please contact us for more information.
Format
Liquid
Buffer
PBS
Preservative
None
Storage
Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
More Infomation

Target

Full Name
bromodomain containing 2
Function
May play a role in spermatogenesis or folliculogenesis (By similarity).
Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.
Biological Process
Neural tube closure Source: Ensembl
Nucleosome assembly Source: UniProtKB
Protein phosphorylation Source: FlyBase
Regulation of transcription by RNA polymerase II Source: UniProtKB
Spermatogenesis Source: ProtInc
Viral process Source: UniProtKB-KW
Cellular Location
Nucleus. Detected on chromatin and nucleosomes.

Yu, Y., Fu, W., Xu, J., Lei, Y., Song, X., Liang, Z., ... & Li, C. (2021). Bromodomain-containing proteins BRD1, BRD2, and BRD13 are core subunits of SWI/SNF complexes and vital for their genomic targeting in Arabidopsis. Molecular Plant.

Jarończyk, K., Sosnowska, K., Zaborowski, A., Pupel, P., Bucholc, M., Małecka, E., ... & Archacki, R. (2021). Bromodomain-containing subunits BRD1, BRD2, and BRD13 are required for proper functioning of SWI/SNF complexes in Arabidopsis. Plant Communications, 100174.

Zhou, L., Han, Y. F., Yuan, C., & Duan, Z. Q. (2021). Screening and bioinformatics analysis of cellular proteins interacting with chicken bromodomain-containing protein 2 in DF-1 cells. British Poultry Science, (just-accepted).

Duan, Z., Han, Y., Zhou, L., Yuan, C., Wang, Y., Zhao, C., ... & Chen, J. (2020). Chicken bromodomain-containing protein 2 interacts with the Newcastle disease virus matrix protein and promotes viral replication. Veterinary Research, 51(1), 1-18.

Wang, L. F., Wang, Y., Yang, Z. Y., Zhao, J., Sun, H. B., & Wu, S. L. (2020). Revealing binding selectivity of inhibitors toward bromodomain-containing proteins 2 and 4 using multiple short molecular dynamics simulations and free energy analyses. SAR and QSAR in Environmental Research, 31(5), 373-398.

Jiang, F., Wei, Q., Li, H., Li, H., Cui, Y., Ma, Y., ... & Chen, Y. (2020). Discovery of novel small molecule induced selective degradation of the bromodomain and extra-terminal (BET) bromodomain protein BRD4 and BRD2 with cellular potencies. Bioorganic & medicinal chemistry, 28(1), 115181.

Zong, J., Li, S., Wang, Y., Mo, W., Sun, R., & Yu, M. (2019). Bromodomain-containing protein 2 promotes lipolysis via ERK/HSL signalling pathway in white adipose tissue of mice. General and comparative endocrinology, 281, 105-116.

Hishiki, K., Akiyama, M., Kanegae, Y., Ozaki, K., Ohta, M., Tsuchitani, E., ... & Yamada, H. (2018). NF-κB signaling activation via increases in BRD2 and BRD4 confers resistance to the bromodomain inhibitor I-BET151 in U937 cells. Leukemia research, 74, 57-63.

Lee, D. J., Hwang, J. H., Ha, J., Yu, G. E., Kwon, S., Park, D. H., ... & Kim, C. W. (2018). Identification of a bromodomain-containing protein 2 (BRD2) gene polymorphic variant and its effects on pork quality traits in berkshire pigs. Korean journal for food science of animal resources, 38(4), 703.

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For research use only. Not intended for any clinical use.

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