BRD2

This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010]

bromodomain containing 2

May play a role in spermatogenesis or folliculogenesis (By similarity).
Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.

Neural tube closure Source: Ensembl
Nucleosome assembly Source: UniProtKB
Protein phosphorylation Source: FlyBase
Regulation of transcription by RNA polymerase II Source: UniProtKB
Spermatogenesis Source: ProtInc
Viral process Source: UniProtKB-KW

Nucleus. Detected on chromatin and nucleosomes.