Human Recombinant CCR8-VLP protein, Flag & His-Strep Tag (V2LY-0526-LY2649)

Name: Human Recombinant CCR8-VLP protein, Flag & His-Strep Tag
SKU: V2LY-0526-LY2649
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

Flag & His-Strep Tag

Protein Construction

This product is Human Recombinant CCR8-VLP protein, Flag & His-Strep Tag consist of Amino Acid: 1-318 and predicts a molecular mass of 42.61 kDa.

Molecule Mass

42.61 kDa

Sequence

Amino Acid: 1-318

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

MES, NaCl, Glycerol, CaCl2, Arginine

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -70°C. Store it under sterile conditions at -70°C or lower. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

C-C Motif Chemokine Receptor 8

Function

Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.

Biological Process

Calcium-mediated signaling Source: GO_Central
Cell adhesion Source: ProtInc
Cell chemotaxis Source: GO_Central
Chemotaxis Source: ProtInc
G protein-coupled receptor signaling pathway Source: Reactome
Immune response Source: GO_Central
Positive regulation of cytosolic calcium ion concentration Source: GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 1-35
Helical: 36-63
Cytoplasmic: 64-73
Helical: 74-93
Extracellular: 94-107
Helical: 108-129
Cytoplasmic: 130-146
Helical: 147-171
Extracellular: 172-202
Helical: 203-222
Cytoplasmic: 223-238
Helical: 239-263
Extracellular: 264-280
Helical: 281-304
Cytoplasmic: 305-355

Verhaegen, Y., Liu, L., Nguyen, T. T., Van Loy, T., Voet, A. R., Schols, D., ... & De Jonghe, S. (2021). Palladium-catalyzed cross-coupling reactions on a bromo-naphthalene scaffold in the search for novel human CC chemokine receptor 8 (CCR8) antagonists. Bioorganic Chemistry, 107, 104560.

Fujikawa, M., Koma, Y. I., Hosono, M., Urakawa, N., Tanigawa, K., Shimizu, M., ... & Yokozaki, H. (2021). Chemokine (CC Motif) Ligand 1 Derived from Tumor-Associated Macrophages Contributes to Esophageal Squamous Cell Carcinoma Progression via CCR8-Mediated Akt/Proline-Rich Akt Substrate of 40 kDa/Mammalian Target of Rapamycin Pathway. The American Journal of Pathology, 191(4), 686-703.

Nagai, R., Nagira, M., Nogami, W., Hirata, M., Ueyama, A., Yoshikawa, M., ... & Nagira, Y. (2021). 873 S-531011, a novel anti-human CCR8 antibody: anti-tumor responses through depletion of tumor-infiltrating CCR8-positive Tregs.

Korbecki, J., Grochans, S., Gutowska, I., Barczak, K., & Baranowska-Bosiacka, I. (2020). CC chemokines in a tumor: a review of pro-cancer and anti-cancer properties of receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 ligands. International journal of molecular sciences, 21(20), 7619.

Cadilha, B. L., Dorman, K., Huynh, D., Lorenzini, T., Vänttinen, M., Benmebarek, M. R., ... & Kobold, S. (2020). P06. 03 CC chemokine receptor 8 tumor-directed recruitment enables CAR T cells to reject solid tumors.

Dépis, F., Hu, C., Weaver, J., McGrath, L., Klebanov, B., Buggé, J., ... & Shaffer, D. R. (2020). Preclinical evaluation of JTX-1811, an anti-CCR8 antibody with enhanced ADCC activity, for preferential depletion of tumor-infiltrating regulatory T cells.

Berenguer, J., Lagerweij, T., Zhao, X. W., Dusoswa, S., Van Der Stoop, P., Westerman, B., ... & Wurdinger, T. (2018). Glycosylated extracellular vesicles released by glioblastoma cells are decorated by CCL18 allowing for cellular uptake via chemokine receptor CCR8. Journal of extracellular vesicles, 7(1), 1446660.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant CCR8 (Nanodisc) protein, His Tag (CAT#: V2LY-0526-LY2647)

Human Recombinant CCR8 (Nanodisc) protein, His & Flag Tag (CAT#: V2LY-0526-LY2648)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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