Human Recombinant CD48 protein, hFc Tag (V2LY-0526-LY2889)

Name: Human Recombinant CD48 protein, hFc Tag
SKU: V2LY-0526-LY2889
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

hFc Tag

Protein Construction

This product is Human Recombinant CD48 protein, hFc Tag consist of Amino Acid: 1-220 and predicts a molecular mass of 49.1 kDa.

Molecule Mass

49.1 kDa

Verified

HPLC

Sequence

Amino Acid: 1-220

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥90% as determined by SDS-PAGE. ≥90% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

CD48 Molecule

Function

Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation.

Biological Process

Defense response Source: ProtInc
Leukocyte migration Source: Reactome
Regulation of adaptive immune response Source: InterPro

Cellular Location

Cell membrane

Wang, Z., He, L., Li, W., Xu, C., Zhang, J., Wang, D., ... & Li, M. (2021). GDF15 induces immunosuppression via CD48 on regulatory T cells in hepatocellular carcinoma. Journal for immunotherapy of cancer, 9(9).

Ziblat, A., Iraolagoitia, X. L. R., Nuñez, S. Y., Torres, N. I., Secchiari, F., Sierra, J. M., ... & Zwirner, N. W. (2021). Circulating and Tumor-Infiltrating NK Cells From Clear Cell Renal Cell Carcinoma Patients Exhibit a Predominantly Inhibitory Phenotype Characterized by Overexpression of CD85j, CD45, CD48 and PD-1. Frontiers in immunology, 12, 2143.

Wang, Z., Xie, C., Li, Y., Cai, J., Tang, J., Jian, J., ... & Lu, Y. (2020). Molecular characterization and expression of CD48 in Nile tilapia (Oreochromis niloticus) in response to different stimulus. Fish & shellfish immunology, 97, 515-522.

Martínez-Vicente, P., Farré, D., Engel, P., & Angulo, A. (2020). Divergent Traits and Ligand-Binding Properties of the Cytomegalovirus CD48 Gene Family. Viruses, 12(8), 813.

Wang, Z., Xiao, Y., Guan, W., Wang, M., Chen, J., Zhang, L., ... & Yu, L. (2020). Acute myeloid leukemia immune escape by epigenetic CD48 silencing. Clinical Science, 134(2), 261-271.

Zou, C., Zhu, C., Guan, G., Guo, Q., Liu, T., Shen, S., ... & Cheng, W. (2019). CD48 is a key molecule of immunomodulation affecting prognosis in glioma. OncoTargets and therapy, 12, 4181.

Pahima, H., Puzzovio, P. G., & Levi-Schaffer, F. (2019). 2B4 and CD48: A powerful couple of the immune system. Clinical Immunology, 204, 64-68.

Martinez-Vicente, P., Farré, D., Sánchez, C., Alcamí, A., Engel, P., & Angulo, A. (2019). Subversion of natural killer cell responses by a cytomegalovirus-encoded soluble CD48 decoy receptor. PLoS pathogens, 15(4), e1007658.

Huang, C. H., Liao, Y. J., Chiou, T. J., Huang, H. T., Lin, Y. H., & Twu, Y. C. (2019). TGF-β regulated leukemia cell susceptibility against NK targeting through the down-regulation of the CD48 expression. Immunobiology, 224(5), 649-658.

Liu, R., Wu, C., Li, L., Chi, F., Zhang, T., Xu, Y., ... & Wang, L. (2019). CD48 and α7 nicotinic acetylcholine receptor synergistically regulate fimH-mediated Escherichia coli K1 penetration and neutrophil transmigration across human brain microvascular endothelial cells. The Journal of infectious diseases, 219(3), 470-479.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant CD48 protein, Biotin Conjugated, hFc & AVI Tag (CAT#: V2LY-0526-LY2888)

Human Recombinant CD48 protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY2890)

Human Recombinant CD48 protein, His Tag (CAT#: V2LY-0526-LY2891)

Mouse Recombinant CD48 protein, hFc Tag (CAT#: V2LY-0526-LY8037)

Mouse Recombinant CD48 protein, Biotin Conjugated, His Tag (CAT#: V2LY-0526-LY8038)

Mouse Recombinant CD48 protein, His Tag (CAT#: V2LY-0526-LY8039)

Rat Recombinant CD48 protein, hFc Tag (CAT#: V2LY-0526-LY9249)

Rat Recombinant CD48 protein, His Tag (CAT#: V2LY-0526-LY9250)

Rhesus Recombinant CD48 protein, hFc Tag (CAT#: V2LY-0526-LY9686)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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