Human Recombinant CEACAM5 protein, APC Conjugated, His Tag (V2LY-0526-LY3084)

Name: Human Recombinant CEACAM5 protein, APC Conjugated, His Tag
SKU: V2LY-0526-LY3084
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant CEACAM5 protein, APC Conjugated, His Tag consist of Amino Acid: 1-685 and predicts a molecular mass of 74.6 kDa.

Molecule Mass

74.6 kDa

Conjugates

APC

Sequence

Amino Acid: 1-685

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Twelve months from date of receipt at -20°C to -70°C in lyophilized form and 3 months at -70°C under sterile conditions after reconstitution. Protect from prolonged exposure to light and avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Carcinoembryonic Antigen Related Cell Adhesion Molecule 5

Function

Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, PubMed:10910050, PubMed:10864933).
Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308).
Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050).
(Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.

Biological Process

Apoptotic process Source: UniProtKB-KW
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
Homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
Homotypic cell-cell adhesion Source: UniProtKB
Leukocyte migration Source: Reactome
Negative regulation of anoikis Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of myotube differentiation Source: UniProtKB

Cellular Location

Cell membrane; Apical cell membrane; Cell surface. Localized to the apical glycocalyx surface.

PTM

Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.

Scoazec, J. Y., Bauchet, A. L., Adam, J., Rochaix, P., MacGrogan, G., Kim, J. E., ... & Lefebvre, A. M. (2021). 1313P Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) tumor expression in a phase I/II study of tusamitamab ravtansine (SAR408701) in patients (pts) with advanced non-small cell lung cancer (NSCLC). Annals of Oncology, 32, S1011.

Adam, J., Lefebvre, A. M., Nicolazzi, C., Larois, C., Attenot, F., Falda-Buscaiot, F., ... & Henry, C. (2021). 19P Therapeutic targets in non-small cell lung cancer: Preclinical and human studies of carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) expression and its associated molecular landscape. Annals of Oncology, 32, S1381.

Gazzah, A., Ricordel, C., Cousin, S., Cho, B. C., Calvo, E., Kim, T. M., ... & Barlesi, F. (2020). Efficacy and safety of the antibody-drug conjugate (ADC) SAR408701 in patients (pts) with non-squamous non-small cell lung cancer (NSQ NSCLC) expressing carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5).

Wan, W., Ye, Y., Wang, H., Li, L., Gu, Y., Yang, L., ... & Meng, Z. (2019). Platelet Carcinoembryonic Antigen Cell Adhesion Molecule 5 (CEACAM5) as a Possible Novel Diagnostic Tool for Evaluation of Acute Coronary Syndrome. Medical science monitor: international medical journal of experimental and clinical research, 25, 9864.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus Recombinant CEACAM5 protein, hFc Tag (CAT#: V2LY-0526-LY1462)

Cynomolgus Recombinant CEACAM5 protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY1463)

Cynomolgus Recombinant CEACAM5 protein, His Tag (CAT#: V2LY-0526-LY1464)

Cynomolgus Recombinant CEACAM5 protein, His Tag-1 (CAT#: V2LY-0526-LY1465)

Cynomolgus Recombinant CEACAM5 protein, His Tag-2 (CAT#: V2LY-0526-LY1466)

Human Recombinant CEACAM5 protein, A3-B3 Domain, His Tag (CAT#: V2LY-0526-LY3081)

Human Recombinant CEACAM5 protein, AF488 Conjugated, His Tag (CAT#: V2LY-0526-LY3082)

Human Recombinant CEACAM5 protein, AF647 Conjugated, His Tag (CAT#: V2LY-0526-LY3083)

Human Recombinant CEACAM5 protein, Biotin Conjugated, hFc & AVI Tag (CAT#: V2LY-0526-LY3085)

Human Recombinant CEACAM5 protein, hFc Tag (CAT#: V2LY-0526-LY3086)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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