Human Recombinant CRTAM protein, Biotin Conjugated, His Tag (V2LY-0526-LY3386)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and IFNG/interferon-gamma secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952).
Regulates CD8+ T-cell proliferation in response to T-cell receptor (TCR) activation (By similarity).
Appears to be dispensable for CD8+ T-cell-mediated cytotoxicity (By similarity).
Interaction with SCRIB promotes the late phase of cellular polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG, IL17 and IL22 production (By similarity).
By interacting with CADM1 on CD8+ dendritic cells, regulates the retention of activated CD8+ T-cells within the draining lymph node (By similarity).
Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (By similarity).
Interaction with CADM1 promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (By similarity).
Cell recognition Source: HGNC-UCL
Detection of stimulus Source: HGNC-UCL
Detection of tumor cell Source: HGNC-UCL
Establishment of T cell polarity Source: UniProtKB
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
Lymphocyte migration into lymphoid organs Source: UniProtKB
Negative regulation of activated T cell proliferation Source: UniProtKB
Positive regulation of cytokine production Source: HGNC-UCL
Positive regulation of interferon-gamma production Source: UniProtKB
Positive regulation of natural killer cell mediated cytotoxicity Source: HGNC-UCL
Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Source: HGNC-UCL
Regulation of CD8-positive, alpha-beta T cell activation Source: UniProtKB
Regulation of immune response Source: Reactome
Regulation of T cell activation Source: UniProtKB
Regulation of T cell differentiation Source: UniProtKB
Helical: 288-308
Cytoplasmic: 309-393
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Alternative Versions
Human Recombinant CRTAM protein, His Tag (CAT#: V2LY-0526-LY3385)
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Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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