CRTAM

CRTAM (Cytotoxic And Regulatory T Cell Molecule) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include receptor binding. An important paralog of this gene is CADM1.

Full Name

Cytotoxic And Regulatory T Cell Molecule

Function

Mediates heterophilic cell-cell adhesion which regulates the activation, differentiation and tissue retention of various T-cell subsets (By similarity).

Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and IFNG/interferon-gamma secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952).

Regulates CD8+ T-cell proliferation in response to T-cell receptor (TCR) activation (By similarity).

Appears to be dispensable for CD8+ T-cell-mediated cytotoxicity (By similarity).

Interaction with SCRIB promotes the late phase of cellular polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG, IL17 and IL22 production (By similarity).

By interacting with CADM1 on CD8+ dendritic cells, regulates the retention of activated CD8+ T-cells within the draining lymph node (By similarity).

Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (By similarity).

Interaction with CADM1 promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (By similarity).

Biological Process

Adaptive immune response Source: UniProtKB-KW
Cell recognition Source: HGNC-UCL
Detection of stimulus Source: HGNC-UCL
Detection of tumor cell Source: HGNC-UCL
Establishment of T cell polarity Source: UniProtKB
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
Lymphocyte migration into lymphoid organs Source: UniProtKB
Negative regulation of activated T cell proliferation Source: UniProtKB
Positive regulation of cytokine production Source: HGNC-UCL
Positive regulation of interferon-gamma production Source: UniProtKB
Positive regulation of natural killer cell mediated cytotoxicity Source: HGNC-UCL
Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Source: HGNC-UCL
Regulation of CD8-positive, alpha-beta T cell activation Source: UniProtKB
Regulation of immune response Source: Reactome
Regulation of T cell activation Source: UniProtKB
Regulation of T cell differentiation Source: UniProtKB

Cellular Location

Cell membrane. In a subset of CD4+ T-cells, colocalizes with SCRIB at the immunological synapse during the late phase of T-cell activation.

Topology

Extracellular: 18-287
Helical: 288-308
Cytoplasmic: 309-393