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IFNAR1 Matched Antibody Pair (604) (APMAB-604LY)

This antibody pair set can be used for detecting and quantifying protein level of human IFNAR1.
See all IFNAR1 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-IFNAR1 polyclonal antibody, 100 ug
Detection Antibody
Anti-IFNAR1 Mouse monoclonal, IgG2a antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. [provided by RefSeq, Jul 2008]
Alternative Names
Interferon Alpha And Beta Receptor Subunit 1
Entrez Gene ID
3454
UniProt ID
P17181

Abolhassani, H., Landegren, N., Bastard, P., Materna, M., Modaresi, M., Du, L., ... & Pan-Hammarström, Q. (2022). Inherited IFNAR1 deficiency in a child with both critical COVID-19 pneumonia and multisystem inflammatory syndrome. Journal of Clinical Immunology, 42(3), 471-483.

Khanmohammadi, S., Rezaei, N., Khazaei, M., & Shirkani, A. (2022). A case of autosomal recessive interferon alpha/beta receptor alpha chain (IFNAR1) deficiency with severe COVID-19. Journal of clinical immunology, 1-6.

Bastard, P., Hsiao, K. C., Zhang, Q., Choin, J., Best, E., Chen, J., ... & Casanova, J. L. (2022). A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes. Journal of Experimental Medicine, 219(6), e20220028.

Bastard, P., Manry, J., Chen, J., Rosain, J., Seeleuthner, Y., AbuZaitun, O., ... & Zhang, S. Y. (2021). Herpes simplex encephalitis in a patient with a distinctive form of inherited IFNAR1 deficiency. The Journal of clinical investigation, 131(1).

Xu, F., Wang, H., Tian, J., & Xu, H. (2021). Down-regulation of ID2-AS1 alleviates the neuronal injury induced by 1-methy1-4-phenylpyridinium in human neuroblastoma cell line SH-SY5Y cells through regulating miR-199a-5p/IFNAR1/JAK2/STAT1 Axis. Neurochemical Research, 46, 2192-2203.

Shemesh, M., Lochte, S., Piehler, J., & Schreiber, G. (2021). IFNAR1 and IFNAR2 play distinct roles in initiating type I interferon–induced JAK-STAT signaling and activating STATs. Science signaling, 14(710), eabe4627.

Saminathan, M., Singh, K. P., Vineetha, S., Maity, M., Biswas, S. K., Manjunathareddy, G. B., ... & Mertens, P. P. C. (2020). Virological, immunological and pathological findings of transplacentally transmitted bluetongue virus serotype 1 in IFNAR1-blocked mice during early and mid gestation. Scientific Reports, 10(1), 2164.

Tian, J., Kang, H., Huang, J., Li, Z., Pan, Y., Li, Y., ... & Qu, L. (2020). Feline calicivirus strain 2280 p30 antagonizes type I interferon-mediated antiviral innate immunity through directly degrading IFNAR1 mRNA. PLoS Pathogens, 16(10), e1008944.

Hernandez, N., Bucciol, G., Moens, L., Le Pen, J., Shahrooei, M., Goudouris, E., ... & Bossuyt, X. (2019). Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reaction to measles and yellow fever live vaccines. Journal of Experimental Medicine, 216(9), 2057-2070.

Zhang, G., Deweerd, N. A., Stifter, S. A., Liu, L., Zhou, B., Wang, W., ... & Feng, C. G. (2018). A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans. Nature communications, 9(1), 1-9.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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