IFNAR1 Matched Antibody Pair (604) (APMAB-604LY)

Name: IFNAR1 Matched Antibody Pair (604)
SKU: APMAB-604LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet References Q & As Review & reward Protocols Associated Products

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Rabbit anti-IFNAR1 polyclonal antibody, 100 ug

Detection Antibody

Anti-IFNAR1 Mouse monoclonal, IgG2a antibody, 20 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. [provided by RefSeq, Jul 2008]

Alternative Names

Interferon Alpha And Beta Receptor Subunit 1

Entrez Gene ID

3454

UniProt ID

P17181

More Infomation

Abolhassani, H., Landegren, N., Bastard, P., Materna, M., Modaresi, M., Du, L., ... & Pan-Hammarström, Q. (2022). Inherited IFNAR1 deficiency in a child with both critical COVID-19 pneumonia and multisystem inflammatory syndrome. Journal of Clinical Immunology, 42(3), 471-483.

Khanmohammadi, S., Rezaei, N., Khazaei, M., & Shirkani, A. (2022). A case of autosomal recessive interferon alpha/beta receptor alpha chain (IFNAR1) deficiency with severe COVID-19. Journal of clinical immunology, 1-6.

Bastard, P., Hsiao, K. C., Zhang, Q., Choin, J., Best, E., Chen, J., ... & Casanova, J. L. (2022). A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes. Journal of Experimental Medicine, 219(6), e20220028.

Bastard, P., Manry, J., Chen, J., Rosain, J., Seeleuthner, Y., AbuZaitun, O., ... & Zhang, S. Y. (2021). Herpes simplex encephalitis in a patient with a distinctive form of inherited IFNAR1 deficiency. The Journal of clinical investigation, 131(1).

Xu, F., Wang, H., Tian, J., & Xu, H. (2021). Down-regulation of ID2-AS1 alleviates the neuronal injury induced by 1-methy1-4-phenylpyridinium in human neuroblastoma cell line SH-SY5Y cells through regulating miR-199a-5p/IFNAR1/JAK2/STAT1 Axis. Neurochemical Research, 46, 2192-2203.

Shemesh, M., Lochte, S., Piehler, J., & Schreiber, G. (2021). IFNAR1 and IFNAR2 play distinct roles in initiating type I interferon–induced JAK-STAT signaling and activating STATs. Science signaling, 14(710), eabe4627.

Saminathan, M., Singh, K. P., Vineetha, S., Maity, M., Biswas, S. K., Manjunathareddy, G. B., ... & Mertens, P. P. C. (2020). Virological, immunological and pathological findings of transplacentally transmitted bluetongue virus serotype 1 in IFNAR1-blocked mice during early and mid gestation. Scientific Reports, 10(1), 2164.

Tian, J., Kang, H., Huang, J., Li, Z., Pan, Y., Li, Y., ... & Qu, L. (2020). Feline calicivirus strain 2280 p30 antagonizes type I interferon-mediated antiviral innate immunity through directly degrading IFNAR1 mRNA. PLoS Pathogens, 16(10), e1008944.

Hernandez, N., Bucciol, G., Moens, L., Le Pen, J., Shahrooei, M., Goudouris, E., ... & Bossuyt, X. (2019). Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reaction to measles and yellow fever live vaccines. Journal of Experimental Medicine, 216(9), 2057-2070.

Zhang, G., Deweerd, N. A., Stifter, S. A., Liu, L., Zhou, B., Wang, W., ... & Feng, C. G. (2018). A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans. Nature communications, 9(1), 1-9.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Pig IFNAR1 ELISA Kit (CAT#: V2LY-0626-LY983)

Human Recombinant IFNAR1 protein, ECD, His Tag (CAT#: V2LY-0526-LY5043)

Human Recombinant IFNAR1 protein, hFc Tag (CAT#: V2LY-0526-LY5044)

Human Recombinant IFNAR1 protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY5045)

Mouse Recombinant IFNAR1 protein, His Tag (CAT#: V2LY-0526-LY8567)

Rabbit Recombinant IFNAR1 protein, His Tag (CAT#: V2LY-0526-LY9137)

Rat Recombinant IFNAR1 protein, His Tag (CAT#: V2LY-0526-LY9494)

Rhesus Recombinant IFNAR1 protein (CAT#: V2LY-0526-LY9760)

Rhesus Recombinant IFNAR1 protein, hFc Tag (CAT#: V2LY-0526-LY9761)

Rhesus Recombinant IFNAR1 protein, His Tag (CAT#: V2LY-0526-LY9762)

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Rabbit Anti-IFNAR1 Recombinant Antibody (A389) (CAT#: CBMAB-AP10817LY)

Pig IFNAR1 ELISA Kit (CAT#: V2LY-0626-LY983)

Rabbit Anti-IFNAR1 Recombinant Antibody (
1B12) (CAT#: V2LY-0725-LY785)

Mouse Anti-IFNAR1 Recombinant Antibody (85228) (CAT#: CBMAB-I1725-YY)

Rabbit Anti-IFNAR1 Recombinant Antibody (A390) (CAT#: CBMAB-AP10818LY)

Mouse Anti-IFNAR1 Recombinant Antibody (CBYY-I1298) (CAT#: CBMAB-I2467-YY)

Mouse Recombinant IFNAR1 protein, His Tag (CAT#: V2LY-0526-LY8567)

Mouse Anti-IFNAR1 Recombinant Antibody (1H2) (CAT#: CBMAB-A4282-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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