Rabbit Anti-IFNAR1 Recombinant Antibody (A389) (CBMAB-AP10817LY)

Name: Rabbit Anti-IFNAR1 Recombinant Antibody (A389)
SKU: CBMAB-AP10817LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

A389

Application

FC, IHC, IP, WB

Immunogen

Recombinant protein of human IFNAR1

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

Affinity purity

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Interferon Alpha And Beta Receptor Subunit 1

Introduction

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. [provided by RefSeq, Jul 2008]

Entrez Gene ID

Human	3454
Mouse	15975
Rat	288264

UniProt ID

Human	P17181
Mouse	P33896
Rat	D3ZDS9

Alternative Names

Interferon Alpha And Beta Receptor Subunit 1

Function

A10913

Biological Process

Cellular response to interferon-alpha Source: UniProtKB
Cytokine-mediated signaling pathway Source: GO_Central
Positive regulation of cellular respiration Source: ARUK-UCL
Receptor signaling pathway via JAK-STAT Source: ProtInc
Response to lipopolysaccharide Source: UniProtKB
Response to virus Source: ProtInc
Type I interferon signaling pathway Source: UniProtKB

Cellular Location

Isoform 1: Lysosome; Cell membrane; Late endosome. Interferon binding triggers internalization of the receptor from the cell membrane into endosomes and then into lysosomes.

Topology

Extracellular: 28-436
Helical: 437-457
Cytoplasmic: 458-557

PTM

Ubiquitinated, leading to its internalization and degradation (PubMed:14532120, PubMed:15337770). Polyubiquitinated via 'Lys-48'-linked and 'Lys-63'-linked ubiquitin chains, leading to receptor internalization and lysosomal degradation (PubMed:18056411). The 'Lys-63'-linked ubiquitin chains are cleaved off by the BRISC complex (PubMed:24075985).
Phosphorylated on serine residues in response to interferon binding; this promotes interaction with FBXW11 and ubiquitination (PubMed:14532120, PubMed:15337770, PubMed:24075985). Phosphorylated on tyrosine residues by TYK2 tyrosine kinase (PubMed:7526154). Phosphorylated on tyrosine residues in response to interferon (PubMed:10049744).
Palmitoylation at Cys-463 is required for the activation of STAT1 and STAT2.

Abolhassani, H., Landegren, N., Bastard, P., Materna, M., Modaresi, M., Du, L., ... & Pan-Hammarström, Q. (2022). Inherited IFNAR1 deficiency in a child with both critical COVID-19 pneumonia and multisystem inflammatory syndrome. Journal of Clinical Immunology, 42(3), 471-483.

Khanmohammadi, S., Rezaei, N., Khazaei, M., & Shirkani, A. (2022). A case of autosomal recessive interferon alpha/beta receptor alpha chain (IFNAR1) deficiency with severe COVID-19. Journal of clinical immunology, 1-6.

Bastard, P., Hsiao, K. C., Zhang, Q., Choin, J., Best, E., Chen, J., ... & Casanova, J. L. (2022). A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes. Journal of Experimental Medicine, 219(6), e20220028.

Bastard, P., Manry, J., Chen, J., Rosain, J., Seeleuthner, Y., AbuZaitun, O., ... & Zhang, S. Y. (2021). Herpes simplex encephalitis in a patient with a distinctive form of inherited IFNAR1 deficiency. The Journal of clinical investigation, 131(1).

Xu, F., Wang, H., Tian, J., & Xu, H. (2021). Down-regulation of ID2-AS1 alleviates the neuronal injury induced by 1-methy1-4-phenylpyridinium in human neuroblastoma cell line SH-SY5Y cells through regulating miR-199a-5p/IFNAR1/JAK2/STAT1 Axis. Neurochemical Research, 46, 2192-2203.

Shemesh, M., Lochte, S., Piehler, J., & Schreiber, G. (2021). IFNAR1 and IFNAR2 play distinct roles in initiating type I interferon–induced JAK-STAT signaling and activating STATs. Science signaling, 14(710), eabe4627.

Saminathan, M., Singh, K. P., Vineetha, S., Maity, M., Biswas, S. K., Manjunathareddy, G. B., ... & Mertens, P. P. C. (2020). Virological, immunological and pathological findings of transplacentally transmitted bluetongue virus serotype 1 in IFNAR1-blocked mice during early and mid gestation. Scientific Reports, 10(1), 2164.

Tian, J., Kang, H., Huang, J., Li, Z., Pan, Y., Li, Y., ... & Qu, L. (2020). Feline calicivirus strain 2280 p30 antagonizes type I interferon-mediated antiviral innate immunity through directly degrading IFNAR1 mRNA. PLoS Pathogens, 16(10), e1008944.

Hernandez, N., Bucciol, G., Moens, L., Le Pen, J., Shahrooei, M., Goudouris, E., ... & Bossuyt, X. (2019). Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reaction to measles and yellow fever live vaccines. Journal of Experimental Medicine, 216(9), 2057-2070.

Zhang, G., Deweerd, N. A., Stifter, S. A., Liu, L., Zhou, B., Wang, W., ... & Feng, C. G. (2018). A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans. Nature communications, 9(1), 1-9.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

IFNAR1 Matched Antibody Pair (604) (CAT#: APMAB-604LY)

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Isotype control

For research use only. Not intended for any clinical use.

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