Mouse Anti-KLF15 Recombinant Antibody (7B12-B3-F8) (CBMAB-Z0496-LY)

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Basic Information

Host Animal
Mouse
Clone
7B12-B3-F8
Application
WB
Immunogen
Purified recombinant fragment of human KLF15 expressed in E. Coli.
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Kruppel Like Factor 15
Entrez Gene ID
UniProt ID
Alternative Names
KKLF; DKFZp779M1320
Function
Lysosomal transporter which is essential for liver homeostasis. Required to maintain stability and lysosomal localization of GLMP.
Biological Process
Protein localization to lysosomeISS:UniProtKB
Protein stabilizationISS:UniProtKB
Cellular Location
Lysosome membrane
PTM
Not N-glycosylated.

Fan, L., Sweet, D. R., Fan, E. K., Prosdocimo, D. A., Madera, A., Jiang, Z., ... & Jain, M. K. (2022). Transcription factors KLF15 and PPARδ cooperatively orchestrate genome-wide regulation of lipid metabolism in skeletal muscle. Journal of Biological Chemistry, 298(6).

Suzuki, N., Kanai, A., Suzuki, Y., Ogino, H., & Ochi, H. (2022). Adrenergic receptor signaling induced by Klf15, a regulator of regeneration enhancer, promotes kidney reconstruction. Proceedings of the National Academy of Sciences, 119(33), e2204338119.

Anzai, K., Tsuruya, K., Ida, K., Kagawa, T., Inagaki, Y., & Kamiya, A. (2021). Kruppel-like factor 15 induces the development of mature hepatocyte-like cells from hepatoblasts. Scientific Reports, 11(1), 18551.

Zhao, Y., Song, W., Wang, L., Rane, M. J., Han, F., & Cai, L. (2019). Multiple roles of KLF15 in the heart: Underlying mechanisms and therapeutic implications. Journal of Molecular and Cellular Cardiology, 129, 193-196.

Li, Y., Zhao, M., & Xiao, W. (2018). KLF15 regulates the expression of MMP-3 in human chondrocytes. Journal of Interferon & Cytokine Research, 38(8), 356-362.

Guo, H., Khan, R., Raza, S. H. A., Ning, Y., Wei, D., Wu, S., ... & Zan, L. (2018). KLF15 promotes transcription of KLF3 gene in bovine adipocytes. Gene, 659, 77-83.

Wang, X., He, M., Li, J., Wang, H., & Huang, J. (2018). KLF15 suppresses cell growth and predicts prognosis in lung adenocarcinoma. Biomedicine & Pharmacotherapy, 106, 672-677.

Gu, X., Xu, D., Fu, L., Wang, Y., Mei, C., & Gao, X. (2018). KLF 15 works as an early anti-fibrotic transcriptional regulator in Ang II-induced renal fibrosis via down-regulation of CTGF expression. Kidney and Blood Pressure Research, 42(6), 999-1012.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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