Mouse Recombinant TNFRSF10B protein, His & hFc Tag (V2LY-0526-LY8212)

Name: Mouse Recombinant TNFRSF10B protein, His & hFc Tag
SKU: V2LY-0526-LY8212
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Mouse

Tag

His & hFc Tag

Protein Construction

This product is Mouse Recombinant TNFRSF10B protein, His & hFc Tag consist of Amino Acid: 1-177 and predicts a molecular mass of 41.8 kDa.

Molecule Mass

41.8 kDa

Sequence

Amino Acid: 1-177

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

TNFRSF10B Gene(Protein Coding) TNF Receptor Superfamily Member 10b

Function

Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288).
The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.

Biological Process

Biological Process activation of NF-kappaB-inducing kinase activitySource:UniProtKB2 Publications
Biological Process apoptotic processSource:UniProtKB1 Publication
Biological Process cell surface receptor signaling pathwaySource:ProtInc1 Publication
Biological Process cellular response to mechanical stimulusSource:UniProtKB1 Publication
Biological Process defense response to tumor cellSource:ARUK-UCL1 Publication
Biological Process extrinsic apoptotic signaling pathway via death domain receptorsSource:UniProtKB1 Publication
Biological Process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressSource:UniProtKB1 Publication
Biological Process positive regulation of apoptotic processSource:GO_Central1 Publication
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signalingSource:UniProtKB1 Publication
Biological Process regulation of apoptotic processSource:UniProtKB1 Publication
Biological Process response to endoplasmic reticulum stressSource:UniProtKB1 Publication
Biological Process TRAIL-activated apoptotic signaling pathwaySource:GO_Central1 Publication

Cellular Location

Membrane

Involvement in disease

Squamous cell carcinoma of the head and neck (HNSCC):
A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes.

Topology

Extracellular: 56-210
Helical: 211-231
Cytoplasmic: 232-440

PTM

(Microbial infection) Glycosylated on Arg residue by S.typhimurium protein Ssek3.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant TNFRSF10B protein, ECD, hFc Tag (CAT#: V2LY-0526-LY3642)

Human Recombinant TNFRSF10B protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY3643)

Human Recombinant TNFRSF10B protein, Biotin Conjugated, His Tag (CAT#: V2LY-0526-LY3644)

Human Recombinant TNFRSF10B protein, His Tag (CAT#: V2LY-0526-LY3645)

Mouse Recombinant TNFRSF10B protein, His Tag (CAT#: V2LY-0526-LY8213)

TNFRSF10B Matched Antibody Pair (1216) (CAT#: APMAB-1216LY)

Antibody Pairs

TNFRSF10B Matched Antibody Pair (1216) (CAT#: APMAB-1216LY)

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TNFRSF10B Matched Antibody Pair (1216) (CAT#: APMAB-1216LY)

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Mouse Anti-TNFRSF10B Recombinant Antibody (B-D37) (CAT#: CBMAB-T3018-YJ)

Mouse Anti-TNFRSF10B Recombinant Antibody (6B8) (CAT#: CBMAB-A9256-LY)

Human Recombinant TNFRSF10B protein, ECD, hFc Tag (CAT#: V2LY-0526-LY3642)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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