Mouse Aldh4a1 ELISA Kit (V2LY-0626-LY1794)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.0052 ng/mL
Detection Range
0.01-3 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Mouse
Assay Type
Sandwich
Reactivity
Mouse
Assay Time
1.5 h
Molecule Mass
61.8 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Aldehyde Dehydrogenase 4 Family Member A1
Function
Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.
Biological Process
4-hydroxyproline catabolic process Source: BHF-UCL
Glyoxylate metabolic process Source: Reactome
Proline catabolic process Source: Reactome
Proline catabolic process to glutamate Source: UniProtKB-UniPathway
Proline metabolic process Source: ProtInc
Cellular Location
Mitochondrion matrix
Involvement in disease
Hyperprolinemia 2 (HYRPRO2): An inborn error of proline metabolism resulting in elevated plasma levels of proline and delta-1-pyrroline-5-carboxylate (P5C). The condition is considered to be benign, but affected individuals can exhibit neurological manifestations that vary in severity. Clinical signs include seizures, intellectual deficit and mild developmental delay.

Lorenzo, C., Delgado, P., Busse, C. E., Sanz-Bravo, A., Martos-Folgado, I., Bonzon-Kulichenko, E., ... & Ramiro, A. R. (2021). ALDH4A1 is an atherosclerosis auto-antigen targeted by protective antibodies. Nature, 589(7841), 287-292.

Nagaoka, A., Kunii, Y., Hino, M., Izumi, R., Nagashima, C., Takeshima, A., ... & Yabe, H. (2020). ALDH4A1 expression levels are elevated in postmortem brains of patients with schizophrenia and are associated with genetic variants in enzymes related to proline metabolism. Journal of psychiatric research, 123, 119-127.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

ALDH4A1 Matched Antibody Pair (065) (CAT#: APMAB-065LY)

ALDH4A1 Matched Antibody Pair (066) (CAT#: APMAB-066LY)

Human Recombinant ALDH4A1 protein (CAT#: V2LY-0526-LY2000)

Human Recombinant ALDH4A1 protein, GST Tag (CAT#: V2LY-0526-LY2001)

Antibody Pairs

ALDH4A1 Matched Antibody Pair (065) (CAT#: APMAB-065LY)

ALDH4A1 Matched Antibody Pair (066) (CAT#: APMAB-066LY)

Related Products

Mouse Anti-ALDH4A1 Recombinant Antibody (1A12-A5) (CAT#: CBMAB-A2296-YC)

ALDH4A1 Matched Antibody Pair (065) (CAT#: APMAB-065LY)

ALDH4A1 Matched Antibody Pair (066) (CAT#: APMAB-066LY)

Human Recombinant ALDH4A1 protein (CAT#: V2LY-0526-LY2000)

Mouse Anti-ALDH4A1 Recombinant Antibody (F-1) (CAT#: CBMAB-A2297-YC)

Human Recombinant ALDH4A1 protein, GST Tag (CAT#: V2LY-0526-LY2001)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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