AMIGO2

Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.

Full Name

Adhesion Molecule With Ig Like Domain 2

Function

Biological Process

Brain development Source: GO_Central
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
Homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
Negative regulation of apoptotic process Source: InterPro
Negative regulation of programmed cell death Source: UniProtKB
Positive regulation of synapse assembly Source: Ensembl

Cellular Location

Nucleus; Cell membrane. Associated with nucleus as well as plasma membrane. Restricted to somata of cerebellar as well as hippocampal neurons (By similarity).

Topology

Extracellular: 40-398 aa
Helical: 399-419 aa
Cytoplasmic: 420-522 aa

Anti-AMIGO2 antibodies

Mouse Anti-AMIGO2 Recombinant Antibody (CBYY-C0756) (CBMAB-C2192-YY)

Datasheet

SDS

Target: AMIGO2

Host: Mouse

Antibody Isotype: IgA, κ

Specificity: Human, Mouse, Rat

Clone: CBYY-C0756

Application*: WB, IP, IF, E, P

Mouse Anti-AMIGO2 Recombinant Antibody (273617) (CBMAB-1073-CN)

Datasheet

SDS

Target: AMIGO2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 273617

Application*: WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)