ASPA

This gene encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate. NAA is abundant in the brain where hydrolysis by aspartoacylase is thought to help maintain white matter. This protein is an NAA scavenger in other tissues. Mutations in this gene cause Canavan disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Full Name
Aspartoacylase
Function
Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids.
Biological Process
Aspartate catabolic process Source: ProtInc
Aspartate family amino acid metabolic process Source: Reactome
Central nervous system myelination Source: Ensembl
Positive regulation of oligodendrocyte differentiation Source: Ensembl
Cellular Location
Cytoplasm; Nucleus
Involvement in disease
Canavan disease (CAND): A rare neurodegenerative condition of infancy or childhood characterized by white matter vacuolization and demyelination that gives rise to a spongy appearance. The clinical features are onset in early infancy, atonia of neck muscles, hypotonia, hyperextension of legs and flexion of arms, blindness, severe mental defect, megalocephaly, and death by 18 months on the average.
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Anti-ASPA antibodies

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Mouse Anti-ASPA Recombinant Antibody (5C7) (CBMAB-A3805-YC)

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Target: ASPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 5C7
Application*: WB
Datasheet SDS

Mouse Anti-ASPA Recombinant Antibody (4H4) (CBMAB-A3803-YC)

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Target: ASPA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: 4H4
Application*: WB
Datasheet SDS

Mouse Anti-ASPA Recombinant Antibody (3G7) (CBMAB-A3802-YC)

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Target: ASPA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: 3G7
Application*: WB
Datasheet SDS

Mouse Anti-ASPA Recombinant Antibody (3G5) (CBMAB-A3801-YC)

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Target: ASPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 3G5
Application*: IH, WB
Datasheet SDS

Mouse Anti-ASPA Recombinant Antibody (3C11) (CBMAB-A3800-YC)

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Target: ASPA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3C11
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-ASPA Recombinant Antibody (2D2) (CBMAB-A3799-YC)

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Target: ASPA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: 2D2
Application*: IH, WB
Datasheet SDS

Mouse Anti-ASPA Recombinant Antibody (1A11) (CBMAB-A3798-YC)

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Target: ASPA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: 1A11
Application*: IH
Datasheet SDS

ASPA Matched Antibody Pair (110) (APMAB-110LY)

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Target: ASPA
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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