BRDG1

The protein encoded by this gene functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is directly phosphorylated by Tec in vitro where it participates in a postive feedback loop, increasing Tec activity. [provided by RefSeq]

Full Name

signal transducing adaptor family member 1

Biological Process

Cellular response to lipopolysaccharide Source: Ensembl
Negative regulation of macrophage chemotaxis Source: Ensembl
Negative regulation of macrophage colony-stimulating factor signaling pathway Source: Ensembl
Negative regulation of microglial cell migration Source: Ensembl
Negative regulation of phosphorylation Source: Ensembl
Negative regulation of ruffle assembly Source: Ensembl
Positive regulation of actin cytoskeleton reorganization Source: Ensembl
Positive regulation of gene expression Source: Ensembl
Positive regulation of microglial cell activation Source: Ensembl
Positive regulation of microglial cell mediated cytotoxicity Source: Ensembl
Positive regulation of phagocytosis, engulfment Source: Ensembl

Cellular Location

Nucleoplasm; Intracellular membrane-bounded organelle