C5AR1
C5AR1 (Complement C5a Receptor 1) is a Protein Coding gene. Diseases associated with C5AR1 include Mannose-Binding Lectin Deficiency and Systemic Lupus Erythematosus. Among its related pathways are Creation of C4 and C2 activators and Complement and coagulation cascades. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and complement component C5a binding. An important paralog of this gene is C5AR2.
Full Name
Complement C5a Receptor 1
Function
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520, PubMed:29300009).
The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099).
Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520).
Biological Process
Activation of MAPK activity Source: ProtInc
Activation of phospholipase C activity Source: ProtInc
Amyloid-beta clearance Source: ARUK-UCL
Animal organ regeneration Source: Ensembl
Apoptotic process Source: Ensembl
Astrocyte activation Source: ARUK-UCL
Cell proliferation in hindbrain Source: Ensembl
Cellular defense response Source: ProtInc
Chemotaxis Source: ProtInc
Cognition Source: ARUK-UCL
Complement component C5a signaling pathway Source: UniProtKB
Complement receptor mediated signaling pathway Source: GO_Central
Defense response to Gram-positive bacterium Source: Ensembl
G protein-coupled receptor signaling pathway Source: Reactome
Immune response Source: ProtInc
Inflammatory response Source: GO_Central
Microglial cell activation Source: ARUK-UCL
mRNA transcription by RNA polymerase II Source: UniProtKB
Negative regulation of neuron apoptotic process Source: Ensembl
Neutrophil chemotaxis Source: Ensembl
Neutrophil degranulation Source: Reactome
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
Positive regulation of angiogenesis Source: Ensembl
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Positive regulation of epithelial cell proliferation Source: UniProtKB
Positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Positive regulation of macrophage chemotaxis Source: Ensembl
Positive regulation of neutrophil chemotaxis Source: Ensembl
Positive regulation of vascular endothelial growth factor production Source: Ensembl
Presynapse organization Source: ARUK-UCL
Regulation of complement activation Source: Reactome
Regulation of tau-protein kinase activity Source: ARUK-UCL
Response to lipopolysaccharide Source: Ensembl
Response to peptidoglycan Source: Ensembl
Sensory perception of chemical stimulus Source: ProtInc
Signal transduction Source: ProtInc
Cellular Location
Cell membrane; Cytoplasmic vesicle. Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles.
Topology
Extracellular: 1-37 aa
Helical: 38-64 aa
Cytoplasmic: 65-69 aa
Helical: 70-93 aa
Extracellular: 94-110 aa
Helical: 111-132 aa
Cytoplasmic: 133-153 aa
Helical: 154-174 aa
Extracellular: 175-200 aa
Helical: 201-226 aa
Cytoplasmic: 227-242 aa
Helical: 243-265 aa
Extracellular: 266-282 aa
Helical: 283-303 aa
Cytoplasmic: 304-350 aa
PTM
Sulfation plays a critical role in the association of C5aR with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small a small peptide agonist (PubMed:11342590). Sulfation at Tyr-14 is important for CHIPS binding (PubMed:21706042).
Phosphorylated on serine residues in response to C5a binding, resulting in internalization of the receptor and short-term desensitization to the ligand. The key residues involved in this process are Ser-334 and Ser-338.
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Datasheet