CASP7

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Full Name
Caspase 7
Function
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
Biological Process
Apoptotic process Source: UniProtKB
Cellular response to staurosporine Source: CAFA
Execution phase of apoptosis Source: GO_Central
Proteolysis Source: UniProtKB
Cellular Location
Cytoplasm
PTM
Cleavages by granzyme B or caspase-10 generate the two active subunits. Propeptide domains can also be cleaved efficiently by caspase-3. Active heterodimers between the small subunit of caspase-7 and the large subunit of caspase-3, and vice versa, also occur.
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Anti-CASP7 antibodies

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Mouse Anti-CASP7 Recombinant Antibody (10-01-62) (CBMAB-C2005-LY)

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Target: CASP7
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 10-01-62
Application*: E, P, IF, IP, WB
Datasheet SDS

Mouse Anti-CASP7 Recombinant Antibody (CBYY-C0981) (CBMAB-C2418-YY)

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Target: CASP7
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYY-C0981
Application*: WB, IP
Datasheet SDS

Mouse Anti-CASP7 Recombinant Antibody (CBYY-C0980) (CBMAB-C2417-YY)

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Target: CASP7
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBYY-C0980
Application*: E, P, IF, IP, WB
Datasheet SDS

Rabbit Anti-CASP7 Recombinant Antibody (CBFYC-0851) (CBMAB-C0906-FY)

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Target: CASP7
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-0851
Application*: WB, IP, IF
Datasheet SDS

Mouse Anti-CASP7 Recombinant Antibody (CBFYC-0850) (CBMAB-C0905-FY)

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Target: CASP7
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-0850
Application*: E, P, IF, IP, WB
Datasheet SDS

Mouse Anti-CASP7 Recombinant Antibody (CBFYC-0849) (CBMAB-C0904-FY)

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Target: CASP7
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Horse
Clone: CBFYC-0849
Application*: E, P, IF, IP, WB
Datasheet SDS

Mouse Anti-CASP7 Recombinant Antibody (CBFYC-0481) (CBMAB-C0529-FY)

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Target: CASP7
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-0481
Application*: E, P, IF, IP, WB
Datasheet SDS

Rabbit Anti-CASP7 Recombinant Antibody (C2885) (CBMAB-C2885-LY)

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Target: CASP7
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: C2885
Application*: WB
Datasheet SDS

Mouse Anti-CASP7 Recombinant Antibody (CBT2044) (V2LY-0625-LY179)

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Target: CASP7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2044
Application*: WB, IH, F
Datasheet SDS

Mouse Anti-CASP7 Recombinant Antibody (CBYY-C0982) (CBMAB-C2419-YY)

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Target: CASP7
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYY-C0982
Application*: E, IF, IP, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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