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CASP7

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Full Name
Caspase 7
Function
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
Biological Process
Apoptotic process Source: UniProtKB
Cellular response to staurosporine Source: CAFA
Execution phase of apoptosis Source: GO_Central
Proteolysis Source: UniProtKB
Cellular Location
Cytoplasm
PTM
Cleavages by granzyme B or caspase-10 generate the two active subunits. Propeptide domains can also be cleaved efficiently by caspase-3. Active heterodimers between the small subunit of caspase-7 and the large subunit of caspase-3, and vice versa, also occur.

Anti-CASP7 antibodies

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Mouse Anti-CASP7 Recombinant Antibody (CBXC-2518) (CBMAB-C5156-CQ)

Datasheet SDS
Target: CASP7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBXC-2518
Application*: WB, IH, P

Mouse Anti-CASP7 Recombinant Antibody (Mch3 1-1-11) (CBMAB-C5155-CQ)

Datasheet SDS
Target: CASP7
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: Mch3 1-1-11
Application*: WB

Mouse Anti-CASP7 Recombinant Antibody (CBXC-2912) (CBMAB-C0232-CQ)

Datasheet SDS
Target: CASP7
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXC-2912
Application*: WB, F, E, IH

Rabbit Anti-CASP7 Recombinant Antibody (CBFYC-0851) (CBMAB-C0906-FY)

Datasheet SDS
Target: CASP7
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBFYC-0851
Application*: WB

Mouse Anti-CASP7 Recombinant Antibody (CBFYC-0850) (CBMAB-C0905-FY)

Datasheet SDS
Target: CASP7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBFYC-0850
Application*: IP, WB

Mouse Anti-CASP7 Recombinant Antibody (CBFYC-0849) (CBMAB-C0904-FY)

Datasheet SDS
Target: CASP7
Host: Mouse
Antibody Isotype: IgG
Specificity: Hamster, Human, Mouse, Rat
Clone: CBFYC-0849
Application*: IH, WB

Mouse Anti-CASP7 Recombinant Antibody (22656) (CBMAB-C4423-LY)

Datasheet SDS
Target: CASP7
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat, Hamster, Human, Monkey
Clone: 22656
Application*: WB

Mouse Anti-CASP7 Recombinant Antibody (40550) (CBMAB-C6444-LY)

Datasheet SDS
Target: CASP7
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Mouse, Rat, Sheep, Rabbit, Hamster, Dog, Human, Pig, Monkey
Clone: 40550
Application*: WB, P, F, IC/IF

Mouse Anti-CASP7 Recombinant Antibody (4G2) (CBMAB-C6981-LY)

Datasheet SDS
Target: CASP7
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Mouse, Rat, Human
Clone: 4G2
Application*: IP, WB

Mouse Anti-CASP7 Recombinant Antibody (CBFYC-0481) (CBMAB-C0529-FY)

Datasheet SDS
Target: CASP7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0481
Application*: P, WB

Mouse Anti-CASP7 Recombinant Antibody (25B881.1) (CBMAB-C0749-LY)

Datasheet SDS
Target: CASP7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 25B881.1
Application*: WB, P

Mouse Anti-CASP7 Recombinant Antibody (4D10B2) (CBMAB-C1702-LY)

Datasheet SDS
Target: CASP7
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 4D10B2
Application*: WB, F, E, IH, MC

Mouse Anti-CASP7 Recombinant Antibody (07-01-11) (CBMAB-C1846-LY)

Datasheet SDS
Target: CASP7
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Dog, Hamster, Monkey, Mouse, Pig, Rabbit, Rat, Sheep
Clone: 07-01-11
Application*: P, WB

Mouse Anti-CASP7 Recombinant Antibody (10-01-62) (CBMAB-C2005-LY)

Datasheet SDS
Target: CASP7
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Hamster, Monkey, Mouse, Rat
Clone: 10-01-62
Application*: P, WB

Rat Anti-CASP7 Recombinant Antibody (11E4) (CBMAB-C2514-LY)

Datasheet SDS
Target: CASP7
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: 11E4
Application*: WB

Mouse Anti-CASP7 Recombinant Antibody (13A244) (CBMAB-C2746-LY)

Datasheet SDS
Target: CASP7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 13A244
Application*: IP, WB

rabbit Anti-CASP7 Recombinant Antibody (13G24D2Q3L) (CBMAB-C2885-LY)

Datasheet SDS
Target: CASP7
Host: rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 13G24D2Q3L
Application*: WB

Mouse Anti-CASP7 Recombinant Antibody (40725) (CBMAB-C6448-LY)

Datasheet SDS
Target: CASP7
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat, Pig, Dog, Rabbit, Sheep
Clone: 40725
Application*: WB, IH

Mouse Anti-CASP7 Recombinant Antibody (4E27) (CBMAB-C6858-LY)

Datasheet SDS
Target: CASP7
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Dog, Hamster, Monkey, Mouse, Pig, Rabbit, Rat, Sheep
Clone: 4E27
Application*: WB

Mouse Anti-CASP7 Recombinant Antibody (7-1-11) (CBMAB-C8418-LY)

Datasheet SDS
Target: CASP7
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 7-1-11
Application*: P, WB

Mouse Anti-CASP7 Recombinant Antibody (8-1-47) (CBMAB-C8936-LY)

Datasheet SDS
Target: CASP7
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 8-1-47
Application*: WB, IP

Mouse Anti-CASP7 Recombinant Antibody (CBYY-C0980) (CBMAB-C2417-YY)

Datasheet SDS
Target: CASP7
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Mouse, Rat, Sheep, Rabbit, Hamster, Dog, Human, Pig, Monkey
Clone: CBYY-C0980
Application*: WB, P, F, IF

Mouse Anti-CASP7 Recombinant Antibody (CBYY-C0981) (CBMAB-C2418-YY)

Datasheet SDS
Target: CASP7
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat, Pig, Dog, Rabbit, Sheep
Clone: CBYY-C0981
Application*: WB, IH

Mouse Anti-CASP7 Recombinant Antibody (CBYY-C0982) (CBMAB-C2419-YY)

Datasheet SDS
Target: CASP7
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C0982
Application*: WB, IP

Mouse Anti-CASP7 Recombinant Antibody (3C120) (CBMAB-C1340-CN)

Datasheet SDS
Target: CASP7
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 3C120
Application*: E

Mouse Anti-CASP7 Recombinant Antibody (9H321) (CBMAB-C1346-CN)

Datasheet SDS
Target: CASP7
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 9H321
Application*: WB

Mouse Anti-CASP7 Recombinant Antibody (MCH3-14) (CBMAB-C9743-LY)

Datasheet SDS
Target: CASP7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MCH3-14
Application*: WB

Mouse Anti-CASP7 Recombinant Antibody (MCH3101.62) (CBMAB-C9742-LY)

Datasheet SDS
Target: CASP7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: MCH3101.62
Application*: WB

Mouse Anti-CASP7 Recombinant Antibody (C7) (CBMAB-CP0115-LY)

Datasheet SDS
Target: CASP7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: C7
Application*: WB

Mouse Anti-CASP7 Recombinant Antibody (CAP1011) (CBMAB-AP802LY)

Datasheet SDS
Target: CASP7
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP1011
Application*: WB

Mouse Anti-CASP7 Recombinant Antibody (MCH3-5) (CBMAB-AP803LY)

Datasheet SDS
Target: CASP7
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: MCH3-5
Application*: WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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