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Mouse Anti-CASP7 Recombinant Antibody (CBFYC-0849) (CBMAB-C0904-FY)

This product is mouse antibody that recognizes CASP7. The antibody CBFYC-0849 can be used for immunoassay techniques such as: IHC, WB.
See all CASP7 antibodies

Summary

Host Animal
Mouse
Specificity
Hamster, Human, Mouse, Rat
Clone
CBFYC-0849
Antibody Isotype
IgG
Application
IHC, WB

Basic Information

Immunogen
Detects an ~37 kD protein, corresponding to the apparent molecular mass of the caspase-7 on SDS-PAGE immunoblots, in samples from human, mouse, rat, monkey and hamster origins
Specificity
Hamster, Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Caspase 7
Introduction
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Entrez Gene ID
Human840
Mouse12369
Rat64026
Monkey697633
UniProt ID
HumanP55210
MouseP97864
RatO88550
MonkeyA0A2K5VRV4
Alternative Names
Caspase 7; Caspase 7, Apoptosis-Related Cysteine Peptidase; Caspase 7, Apoptosis-Related Cysteine Protease; ICE-Like Apoptotic Protease 3; ICE-LAP3; CASP-7; CMH-1; MCH3
Function
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
Biological Process
Apoptotic process Source: UniProtKB
Cellular response to staurosporine Source: CAFA
Execution phase of apoptosis Source: GO_Central
Proteolysis Source: UniProtKB
Cellular Location
Cytoplasm
PTM
Cleavages by granzyme B or caspase-10 generate the two active subunits. Propeptide domains can also be cleaved efficiently by caspase-3. Active heterodimers between the small subunit of caspase-7 and the large subunit of caspase-3, and vice versa, also occur.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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