Mouse Anti-CASP7 Recombinant Antibody (CBYY-C0980) (CBMAB-C2417-YY)

This product is mouse antibody that recognizes CASP7. The antibody CBYY-C0980 can be used for immunoassay techniques such as: WB, IHC-P, FC, IF
See all CASP7 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Mouse, Rat, Sheep, Rabbit, Hamster, Dog, Human, Pig, Monkey

Clone

CBYY-C0980

Antibody Isotype

IgG2b

Application

WB, IHC-P, FC, IF

Basic Information

Specificity

Mouse, Rat, Sheep, Rabbit, Hamster, Dog, Human, Pig, Monkey

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Protein G purified

Buffer

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Caspase 7

Entrez Gene ID

Human	840
Mouse	12369
Rat	64026
Dog	486896
Hamster	100766857
Monkey	697633
Pig	100156777
Rabbit	100101591
Sheep	101122741

UniProt ID

Human	P55210
Mouse	P97864
Rat	O88550
Dog	E2R027
Hamster	P55214
Monkey	A0A2K5VRV4
Pig	K9J6J4
Rabbit	G1T0H6
Sheep	5PTI1

Alternative Names

Ciliogenesis Associated TTC17 Interacting Protein; C2orf62; Ciliogenesis-Associated TTC17-Interacting Protein; Chromosome 2 Open Reading Frame 62;

Function

Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.

Biological Process

Apoptotic process Source: UniProtKB
Cellular response to staurosporine Source: CAFA
Execution phase of apoptosis Source: GO_Central
Proteolysis Source: UniProtKB

Cellular Location

Cytoplasm

PTM

Cleavages by granzyme B or caspase-10 generate the two active subunits. Propeptide domains can also be cleaved efficiently by caspase-3. Active heterodimers between the small subunit of caspase-7 and the large subunit of caspase-3, and vice versa, also occur.

References

Mahib, M. R., Hosojima, S., Kushiyama, H., Kinoshita, T., Shiroishi, T., Suda, T., & Tsuchiya, K. (2020). Caspase‐7 mediates caspase‐1‐induced apoptosis independently of Bid. Microbiology and immunology, 64(2), 143-152.

Safdar, M., Zaheer, S., Khailany, R. A., Parvez, S., Naveed, M., Bhuiyan, P., ... & Junejo, Y. (2020). The Relevance of SNPs at 3′ UTR Region of CASP7 and miR-371b-5p Associated Diseases: A Computational Analysis. Cell Biochemistry and Biophysics, 78(4), 541-557.

Gonçalves, A. V., Margolis, S. R., Quirino, G. F., Mascarenhas, D. P., Rauch, I., Nichols, R. D., ... & Zamboni, D. S. (2019). Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila. PLoS pathogens, 15(6), e1007886.

Pham, B., Eron, S. J., Hill, M. E., Li, X., Fahie, M. A., Hardy, J. A., & Chen, M. (2019). A nanopore approach for analysis of caspase-7 activity in cell lysates. Biophysical journal, 117(5), 844-855.

Shigemura, M., Lecuona, E., Angulo, M., Homma, T., Rodríguez, D. A., Gonzalez-Gonzalez, F. J., ... & Sznajder, J. I. (2018). Hypercapnia increases airway smooth muscle contractility via caspase-7–mediated miR-133a–RhoA signaling. Science translational medicine, 10(457).

Venkatesh, A., Cheng, S. Y., & Punzo, C. (2017). Loss of the cone-enriched caspase-7 does not affect secondary cone death in retinitis pigmentosa. Molecular vision, 23, 944.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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