CBLC

CBL proteins, such as CBLC, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC (MIM 190090) homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling (Keane et al., 1999 [PubMed 10362357]).[supplied by OMIM
Full Name
Cas-Br-M (murine) ecotropic retroviral transforming sequence c
Function
Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.
Biological Process
Cell surface receptor signaling pathway Source: InterPro
Negative regulation of epidermal growth factor-activated receptor activity Source: BHF-UCL
Negative regulation of epidermal growth factor receptor signaling pathway Source: BHF-UCL
Negative regulation of MAP kinase activity Source: BHF-UCL
Protein ubiquitination Source: BHF-UCL
Signal transduction Source: GO_Central
Ubiquitin-dependent protein catabolic process Source: BHF-UCL
Cellular Location
Plasma membrane; Membrane raft
PTM
Phosphorylated on multiple tyrosine residues by SRC. Isoform 1, but not isoform 2, is phosphorylated on tyrosines by EGFR.
Autoubiquitinated when phosphorylated at Tyr-341, enhanced by SRC; suggesting proteasomal degradation.
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Anti-CBLC antibodies

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Mouse Anti-CBLC Recombinant Antibody (CBYY-C1026) (CBMAB-C2463-YY)

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Target: CBLC
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human, Mouse, Rat
Clone: CBYY-C1026
Application*: WB, IP, IF, E, P
Mouse Anti-CBLC Recombinant Antibody (CBYY-C1026)
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Mouse Anti-CBLC Recombinant Antibody (CBFYC-0889) (CBMAB-C0944-FY)

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Target: CBLC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-0889
Application*: WB, IP, IF, E
Mouse Anti-CBLC Recombinant Antibody (CBFYC-0889)
Datasheet SDS

Mouse Anti-CBLC Recombinant Antibody (3F10) (CBMAB-C5990-LY)

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Target: CBLC
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3F10
Application*: E, WB
Mouse Anti-CBLC Recombinant Antibody (3F10)
Datasheet SDS

Mouse Anti-CBLC Recombinant Antibody (3D9) (CBMAB-C5907-LY)

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Target: CBLC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3D9
Application*: WB
Mouse Anti-CBLC Recombinant Antibody (3D9)
Datasheet SDS

Mouse Anti-CBLC Recombinant Antibody (3B4) (CBMAB-C5717-LY)

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Target: CBLC
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 3B4
Application*: F, WB
Mouse Anti-CBLC Recombinant Antibody (3B4)
Datasheet SDS

Mouse Anti-CBLC Recombinant Antibody (01) (CBMAB-C1561-LY)

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Target: CBLC
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 01
Application*: E
Mouse Anti-CBLC Recombinant Antibody (01)
Datasheet SDS

Human Recombinant CBLC protein, GST Tag (V2LY-0526-LY2614)

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Target: CBLC
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-474
Tag: GST Tag
Human Recombinant CBLC protein, GST Tag
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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