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CBLC

CBL proteins, such as CBLC, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC (MIM 190090) homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling (Keane et al., 1999 [PubMed 10362357]).[supplied by OMIM
Full Name
Cas-Br-M (murine) ecotropic retroviral transforming sequence c
Function
Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.
Biological Process
Cell surface receptor signaling pathway Source: InterPro
Negative regulation of epidermal growth factor-activated receptor activity Source: BHF-UCL
Negative regulation of epidermal growth factor receptor signaling pathway Source: BHF-UCL
Negative regulation of MAP kinase activity Source: BHF-UCL
Protein ubiquitination Source: BHF-UCL
Signal transduction Source: GO_Central
Ubiquitin-dependent protein catabolic process Source: BHF-UCL
Cellular Location
Plasma membrane; Membrane raft
PTM
Phosphorylated on multiple tyrosine residues by SRC. Isoform 1, but not isoform 2, is phosphorylated on tyrosines by EGFR.
Autoubiquitinated when phosphorylated at Tyr-341, enhanced by SRC; suggesting proteasomal degradation.

Anti-CBLC antibodies

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Target: CBLC
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXC-2159
Application*: WB, F
Target: CBLC
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXC-0093
Application*: E, WB
Target: CBLC
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-0889
Application*: E
Target: CBLC
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBLC128-LY
Application*: E, WB
Target: CBLC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1027
Application*: WB, F
Target: CBLC
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-C1026
Application*: F, WB
Target: CBLC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4E3
Application*: WB, F
Target: CBLC
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3F10
Application*: E, WB
Target: CBLC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3D9
Application*: WB
Target: CBLC
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 3B4
Application*: C, WB
Target: CBLC
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 01
Application*: E
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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