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CBLC

CBL proteins, such as CBLC, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC (MIM 190090) homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling (Keane et al., 1999 [PubMed 10362357]).[supplied by OMIM

Full Name

Cas-Br-M (murine) ecotropic retroviral transforming sequence c

Function

Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.

Biological Process

Cell surface receptor signaling pathway Source: InterPro
Negative regulation of epidermal growth factor-activated receptor activity Source: BHF-UCL
Negative regulation of epidermal growth factor receptor signaling pathway Source: BHF-UCL
Negative regulation of MAP kinase activity Source: BHF-UCL
Protein ubiquitination Source: BHF-UCL
Signal transduction Source: GO_Central
Ubiquitin-dependent protein catabolic process Source: BHF-UCL

Cellular Location

Plasma membrane; Membrane raft

PTM

Phosphorylated on multiple tyrosine residues by SRC. Isoform 1, but not isoform 2, is phosphorylated on tyrosines by EGFR.
Autoubiquitinated when phosphorylated at Tyr-341, enhanced by SRC; suggesting proteasomal degradation.

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Anti-CBLC antibodies

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Mouse Anti-CBLC Recombinant Antibody (CBYY-C1026) (CBMAB-C2463-YY)

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Target: CBLC

Host: Mouse

Antibody Isotype: IgM, κ

Specificity: Human, Mouse, Rat

Clone: CBYY-C1026

Application*: WB, IP, IF, E, P

Mouse Anti-CBLC Recombinant Antibody (CBFYC-0889) (CBMAB-C0944-FY)

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Target: CBLC

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYC-0889

Application*: WB, IP, IF, E

Mouse Anti-CBLC Recombinant Antibody (3F10) (CBMAB-C5990-LY)

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Target: CBLC

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3F10

Application*: E, WB

Mouse Anti-CBLC Recombinant Antibody (3D9) (CBMAB-C5907-LY)

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Target: CBLC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3D9

Application*: WB

Mouse Anti-CBLC Recombinant Antibody (3B4) (CBMAB-C5717-LY)

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Target: CBLC

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 3B4

Application*: F, WB

Mouse Anti-CBLC Recombinant Antibody (01) (CBMAB-C1561-LY)

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Target: CBLC

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 01

Application*: E

Human Recombinant CBLC protein, GST Tag (V2LY-0526-LY2614)

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Target: CBLC

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: 1-474

Tag: GST Tag

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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