CCS

CCS (Copper Chaperone For Superoxide Dismutase) is a Protein Coding gene. Diseases associated with CCS include Entropion and Amyotrophic Lateral Sclerosis 1. Among its related pathways are Detoxification of Reactive Oxygen Species and Amyotrophic lateral sclerosis (ALS). Gene Ontology (GO) annotations related to this gene include copper ion binding and copper ion transmembrane transporter activity. An important paralog of this gene is SOD1.

Copper Chaperone For Superoxide Dismutase

Delivers copper to copper zinc superoxide dismutase (SOD1).

Cellular response to oxidative stress Source: Reactome
Positive regulation of oxidoreductase activity Source: Ensembl
Protein maturation by copper ion transfer Source: ProtInc
Removal of superoxide radicals Source: GO_Central
Superoxide metabolic process Source: ProtInc

Cytoplasm

Ubiquitinion by XIAP/BIRC4 leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. XIAP/BIRC4 preferentially ubiquitinates at Lys-241.