CD207

CD207 (CD207 Molecule) is a protein coding gene. Diseases associated with CD207 include Birbeck Granule Deficiency and Langerhans Cell Histiocytosis. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology annotations related to this gene include carbohydrate binding and mannose binding.
Full Name
CD207 Molecule
Function
Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.
Biological Process
Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
Defense response to virus Source: UniProtKB
Receptor-mediated endocytosis Source: Reactome
Cellular Location
Membrane. Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.
Involvement in disease
Birbeck granule deficiency (BIRGD): A condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules, Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.
Topology
Cytoplasmic: 1-43
Helical: 44-64
Extracellular: 65-328
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Anti-CD207 antibodies

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Mouse Anti-CD207 Recombinant Antibody (4C7) (CBMAB-C1575-LY)

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Target: CD207
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Mouse, Human, Monkey, Pig
Clone: 4C7
Application*: F, IH
Datasheet SDS

Mouse Anti-CD207 Recombinant Antibody (CBT3295) (V2LY-0625-LY768)

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Target: CD207
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT3295
Application*: F
Datasheet SDS

Mouse Anti-CD207 Recombinant Antibody (2G3) (CBMAB-C0893-LY)

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Target: CD207
Host: Mouse
Antibody Isotype: IgG1, λ
Specificity: Human
Clone: 2G3
Application*: F, IH
Datasheet SDS

Rabbit Anti-CD207 Recombinant Antibody (CBYJL-075) (CBMAB-L0128-YJ)

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Target: CD207
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-075
Application*: IH
Datasheet SDS

Rabbit Anti-CD207 Recombinant Antibody (CBYJL-072) (CBMAB-L0125-YJ)

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Target: CD207
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-072
Application*: WB, IP, F, IF
Datasheet SDS

Mouse Anti-CD207 Recombinant Antibody (CBYJL-070) (CBMAB-L0122-YJ)

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Target: CD207
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJL-070
Application*: WB, E, F, IH
Datasheet SDS

Mouse Anti-CD207 Recombinant Antibody (CBYJL-069) (CBMAB-L0121-YJ)

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Target: CD207
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJL-069
Application*: IF, IP, WB, E, P
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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