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CD207

CD207 (CD207 Molecule) is a protein coding gene. Diseases associated with CD207 include Birbeck Granule Deficiency and Langerhans Cell Histiocytosis. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology annotations related to this gene include carbohydrate binding and mannose binding.
Full Name
CD207 Molecule
Function
Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.
Biological Process
Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
Defense response to virus Source: UniProtKB
Receptor-mediated endocytosis Source: Reactome
Cellular Location
Membrane. Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.
Involvement in disease
Birbeck granule deficiency (BIRGD): A condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules, Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.
Topology
Cytoplasmic: 1-43
Helical: 44-64
Extracellular: 65-328

Anti-CD207 antibodies

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Mouse Anti-CD207 Recombinant Antibody (IHC613) (CBMAB-MA037-YC)

Datasheet SDS
Target: CD207
Host: Mouse
Specificity: Human
Clone: IHC613
Application*: IH

Mouse Anti-CD207 Recombinant Antibody (CBYJL-069) (CBMAB-L0121-YJ)

Datasheet SDS
Target: CD207
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Pig
Clone: CBYJL-069
Application*: F, IH, IC, IF

Mouse Anti-CD207 Recombinant Antibody (CBYJL-070) (CBMAB-L0122-YJ)

Datasheet SDS
Target: CD207
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Pig, Hamster
Clone: CBYJL-070
Application*: F, IH, IC, IF, IC

Mouse Anti-CD207 Recombinant Antibody (CBYJL-072) (CBMAB-L0125-YJ)

Datasheet SDS
Target: CD207
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-072
Application*: F, FN

Rat Anti-CD207 Recombinant Antibody (CBYJL-075) (CBMAB-L0128-YJ)

Datasheet SDS
Target: CD207
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat, Pig
Clone: CBYJL-075
Application*: F, IH, IC, IF, IC

Mouse Anti-CD207 Recombinant Antibody (9H149) (CBMAB-L0129-YJ)

Datasheet SDS
Target: CD207
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9H149
Application*: F

Mouse Anti-CD207 Recombinant Antibody (DCGM4/122D5) (CBMAB-L0130-YJ)

Datasheet SDS
Target: CD207
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog
Clone: DCGM4/122D5
Application*: F, IH, C

Mouse Anti-CD207 Recombinant Antibody (4C7) (CBMAB-C1575-LY)

Datasheet SDS
Target: CD207
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Mouse, Human, Monkey, Rabbit, Pig
Clone: 4C7
Application*: F

Mouse Anti-CD207 Recombinant Antibody (CBFYC-1152) (CBMAB-C1210-FY)

Datasheet SDS
Target: CD207
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-1152
Application*: C, P

Mouse Anti-CD207 Recombinant Antibody (CBFYC-1153) (CBMAB-C1211-FY)

Datasheet SDS
Target: CD207
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Monkey
Clone: CBFYC-1153
Application*: F

Mouse Anti-CD207 Recombinant Antibody (10E2) (CBMAB-C0182-LY)

Datasheet SDS
Target: CD207
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 10E2
Application*: F

Mouse Anti-CD207 Recombinant Antibody (12D6) (CBMAB-C0277-LY)

Datasheet SDS
Target: CD207
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 12D6
Application*: C, P

Mouse Anti-CD207 Recombinant Antibody (2G3) (CBMAB-C0893-LY)

Datasheet SDS
Target: CD207
Host: Mouse
Antibody Isotype: IgG1, λ
Specificity: Human
Clone: 2G3
Application*: IH

Mouse Anti-CD207 Recombinant Antibody (CBYY-C0271) (CBMAB-C0841-YY)

Datasheet SDS
Target: CD207
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Mouse, Human, Monkey, Rabbit, Pig
Clone: CBYY-C0271
Application*: F, IH

Mouse Anti-CD207 Recombinant Antibody (CBYY-C1259) (CBMAB-C2696-YY)

Datasheet SDS
Target: CD207
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: CBYY-C1259
Application*: IS, F

Mouse Anti-CD207 Recombinant Antibody (CBYJL-1011) (CBMAB-L0420-YJ)

Datasheet SDS
Target: CD207
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1011
Application*: F, IC, IF

Mouse Anti-CD207 Recombinant Antibody (CBYJL-1012) (CBMAB-L0421-YJ)

Datasheet SDS
Target: CD207
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog
Clone: CBYJL-1012
Application*: F, IF, C

Mouse Anti-Cd207 Recombinant Antibody (205C1) (CBMAB-L2719-YJ)

Datasheet SDS
Target: Cd207
Host: Mouse
Antibody Isotype: IgM
Specificity: Mouse
Clone: 205C1
Application*: F

Mouse Anti-CD207 Recombinant Antibody (MB22-9F5) (CBMAB-C1790-CQ)

Datasheet SDS
Target: CD207
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MB22-9F5
Application*: F
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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