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Mouse Anti-CD207 Recombinant Antibody (CBT3295) (V2LY-0625-LY768)


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Tested Data
Mouse Anti-CD207 Recombinant Antibody (CBT3295) (V2LY-0625-LY768) in ELISA
Mouse Anti-CD207 Recombinant Antibody (CBT3295) (V2LY-0625-LY768) in ELISA
Mouse Anti-CD207 Recombinant Antibody (CBT3295) (V2LY-0625-LY768) in WB
Mouse Anti-CD207 Recombinant Antibody (CBT3295) (V2LY-0625-LY768) in WB
Mouse Anti-CD207 Recombinant Antibody (CBT3295) (V2LY-0625-LY768) in WB
Mouse Anti-CD207 Recombinant Antibody (CBT3295) (V2LY-0625-LY768) in WB
Mouse Anti-CD207 Recombinant Antibody (CBT3295) (V2LY-0625-LY768) in FC
Mouse Anti-CD207 Recombinant Antibody (CBT3295) (V2LY-0625-LY768) in FC

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT3295
Antibody Isotype
IgG2b
Application
FC

Basic Information

Immunogen
Purified recombinant fragment of human CD207 (AA: extra 155-328) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID
50489
UniProt ID
Q9UJ71
Function
Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.
Biological Process
Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
Defense response to virus Source: UniProtKB
Receptor-mediated endocytosis Source: Reactome
Cellular Location
Membrane. Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.
Involvement in disease
Birbeck granule deficiency (BIRGD): A condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules, Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.
Topology
Cytoplasmic: 1-43
Helical: 44-64
Extracellular: 65-328
More Infomation

Wang, H., Chen, X., Li, S., Zhou, C., Xu, L., Wu, Z., & Chen, X. (2021). Identification and expression analysis of Langerhans cells marker Langerin/CD207 in grass carp, Ctenopharyngodon idella. Gene, 768, 145315.

Wu, B. C., Olivia, N. A., Tembo, J. M., He, Y. X., Zhang, Y. M., Xue, Y., ... & Chen, T. (2021). Loss of the virulence plasmid by Shigella sonnei promotes its interactions with CD207 and CD209 receptors. Journal of Medical Microbiology, 70(3), 001297.

van Dalen, R., Fuchsberger, F. F., Rademacher, C., van Strijp, J. A., & van Sorge, N. M. (2020). A common genetic variation in langerin (CD207) compromises cellular uptake of Staphylococcus aureus. Journal of innate immunity, 12(2), 191-200.

Maarifi, G., Czubala, M. A., Lagisquet, J., Ivory, M. O., Fuchs, K., Papin, L., ... & Blanchet, F. P. (2020). Langerin (CD207) represents a novel interferon-stimulated gene in Langerhans cells. Cellular & molecular immunology, 17(5), 547-549.

Pergolizzi, S., Marino, A., Capillo, G., Aragona, M., Marconi, P., & Lauriano, E. R. (2020). Expression of Langerin/CD 207 and α-smooth muscle actin in ex vivo rabbit corneal keratitis model. Tissue and Cell, 66, 101384.

Lauriano, E. R., Pergolizzi, S., Cascio, P. L., Kuciel, M., Zizzo, N., Guerrera, M. C., ... & Capillo, G. (2020). Expression of Langerin/CD207 in airways, lung and associated lymph nodes of a stranded striped dolphin (Stenella coeruleoalba). Acta histochemica, 122(2), 151471.

van Dalen, R., Jacinto, S., Rumpret, M., Fuchsberger, F. F., van Teijlingen, N. H., Hanske, J., ... & van Sorge, N. M. (2018). Staphylococcus aureus wall teichoic acid is a pathogen-associated molecular pattern that is recognized by langerin (CD207) on skin Langerhans cells. bioRxiv, 238469.

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For research use only. Not intended for any clinical use.

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