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Rabbit Anti-CD207 Recombinant Antibody (CBYJL-072) (CBMAB-L0125-YJ)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBYJL-072
Antibody Isotype
IgG
Application
WB, IP, FC, IF

Basic Information

Immunogen
Synthetic peptide corresponding to residues surrounding Val14 of human Langerin protein.
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:1,000
IF(ICC)1:800
FC1:3,200
IP1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
HEPES, pH 7.5, 100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CD207 Molecule
Introduction
Diseases associated with CD207 include Langerhans Cell Histiocytosis and Birbeck Granule Deficiency. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. CLEC4F is an important paralog of this gene.
Entrez Gene ID
50489
UniProt ID
Q9UJ71
Function
Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.
Biological Process
Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
Defense response to virus Source: UniProtKB
Receptor-mediated endocytosis Source: Reactome
Cellular Location
Membrane. Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.
Involvement in disease
Birbeck granule deficiency (BIRGD): A condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules, Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.
Topology
Cytoplasmic: 1-43
Helical: 44-64
Extracellular: 65-328
More Infomation

Wang, H., Chen, X., Li, S., Zhou, C., Xu, L., Wu, Z., & Chen, X. (2021). Identification and expression analysis of Langerhans cells marker Langerin/CD207 in grass carp, Ctenopharyngodon idella. Gene, 768, 145315.

Wu, B. C., Olivia, N. A., Tembo, J. M., He, Y. X., Zhang, Y. M., Xue, Y., ... & Chen, T. (2021). Loss of the virulence plasmid by Shigella sonnei promotes its interactions with CD207 and CD209 receptors. Journal of Medical Microbiology, 70(3), 001297.

van Dalen, R., Fuchsberger, F. F., Rademacher, C., van Strijp, J. A., & van Sorge, N. M. (2020). A common genetic variation in langerin (CD207) compromises cellular uptake of Staphylococcus aureus. Journal of innate immunity, 12(2), 191-200.

Maarifi, G., Czubala, M. A., Lagisquet, J., Ivory, M. O., Fuchs, K., Papin, L., ... & Blanchet, F. P. (2020). Langerin (CD207) represents a novel interferon-stimulated gene in Langerhans cells. Cellular & molecular immunology, 17(5), 547-549.

Pergolizzi, S., Marino, A., Capillo, G., Aragona, M., Marconi, P., & Lauriano, E. R. (2020). Expression of Langerin/CD 207 and α-smooth muscle actin in ex vivo rabbit corneal keratitis model. Tissue and Cell, 66, 101384.

Lauriano, E. R., Pergolizzi, S., Cascio, P. L., Kuciel, M., Zizzo, N., Guerrera, M. C., ... & Capillo, G. (2020). Expression of Langerin/CD207 in airways, lung and associated lymph nodes of a stranded striped dolphin (Stenella coeruleoalba). Acta histochemica, 122(2), 151471.

van Dalen, R., Jacinto, S., Rumpret, M., Fuchsberger, F. F., van Teijlingen, N. H., Hanske, J., ... & van Sorge, N. M. (2018). Staphylococcus aureus wall teichoic acid is a pathogen-associated molecular pattern that is recognized by langerin (CD207) on skin Langerhans cells. bioRxiv, 238469.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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