Rhesus Recombinant CD207 protein, hFc Tag (V2LY-0526-LY9764)

Name: Rhesus Recombinant CD207 protein, hFc Tag
SKU: V2LY-0526-LY9764
Rating: 5 (1 reviews)

See all CD207 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Rhesus

Tag

hFc Tag

Protein Construction

This product is Rhesus Recombinant CD207 protein, hFc Tag consist of Amino Acid: 65-328 and predicts a molecular mass of 58.3 kDa.

Molecule Mass

58.3 kDa

Sequence

Amino Acid: 65-328

Species

Rhesus

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>85% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

CD207 Molecule

Function

Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.

Biological Process

Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
Defense response to virus Source: UniProtKB
Receptor-mediated endocytosis Source: Reactome

Cellular Location

Membrane. Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.

Involvement in disease

Birbeck granule deficiency (BIRGD): A condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules, Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.

Topology

Cytoplasmic: 1-43
Helical: 44-64
Extracellular: 65-328

Wang, H., Chen, X., Li, S., Zhou, C., Xu, L., Wu, Z., & Chen, X. (2021). Identification and expression analysis of Langerhans cells marker Langerin/CD207 in grass carp, Ctenopharyngodon idella. Gene, 768, 145315.

Wu, B. C., Olivia, N. A., Tembo, J. M., He, Y. X., Zhang, Y. M., Xue, Y., ... & Chen, T. (2021). Loss of the virulence plasmid by Shigella sonnei promotes its interactions with CD207 and CD209 receptors. Journal of Medical Microbiology, 70(3), 001297.

van Dalen, R., Fuchsberger, F. F., Rademacher, C., van Strijp, J. A., & van Sorge, N. M. (2020). A common genetic variation in langerin (CD207) compromises cellular uptake of Staphylococcus aureus. Journal of innate immunity, 12(2), 191-200.

Maarifi, G., Czubala, M. A., Lagisquet, J., Ivory, M. O., Fuchs, K., Papin, L., ... & Blanchet, F. P. (2020). Langerin (CD207) represents a novel interferon-stimulated gene in Langerhans cells. Cellular & molecular immunology, 17(5), 547-549.

Pergolizzi, S., Marino, A., Capillo, G., Aragona, M., Marconi, P., & Lauriano, E. R. (2020). Expression of Langerin/CD 207 and α-smooth muscle actin in ex vivo rabbit corneal keratitis model. Tissue and Cell, 66, 101384.

Lauriano, E. R., Pergolizzi, S., Cascio, P. L., Kuciel, M., Zizzo, N., Guerrera, M. C., ... & Capillo, G. (2020). Expression of Langerin/CD207 in airways, lung and associated lymph nodes of a stranded striped dolphin (Stenella coeruleoalba). Acta histochemica, 122(2), 151471.

van Dalen, R., Jacinto, S., Rumpret, M., Fuchsberger, F. F., van Teijlingen, N. H., Hanske, J., ... & van Sorge, N. M. (2018). Staphylococcus aureus wall teichoic acid is a pathogen-associated molecular pattern that is recognized by langerin (CD207) on skin Langerhans cells. bioRxiv, 238469.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Rhesus Recombinant CD207 protein, hFc Tag?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-CD207 Recombinant Antibody (CBYJL-070) (CAT#: CBMAB-L0122-YJ)

Mouse Anti-CD207 Recombinant Antibody (4C7) (CAT#: CBMAB-C1575-LY)

Rabbit Anti-CD207 Recombinant Antibody (CBYJL-072) (CAT#: CBMAB-L0125-YJ)

Mouse Anti-CD207 Recombinant Antibody (CBYJL-069) (CAT#: CBMAB-L0121-YJ)

Rabbit Anti-CD207 Recombinant Antibody (CBYJL-075) (CAT#: CBMAB-L0128-YJ)

Mouse Anti-CD207 Recombinant Antibody (2G3) (CAT#: CBMAB-C0893-LY)

Mouse Anti-CD207 Recombinant Antibody (CBT3295) (CAT#: V2LY-0625-LY768)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry