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Mouse Anti-CD207 Recombinant Antibody (4C7) (CBMAB-C1575-LY)

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Datasheet
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Basic Information

Host Animal
Mouse
Clone
4C7
Application
FC, IHC
Immunogen
Langerin extracellular domain-Fc fusion protein
Host Species
Mouse
Specificity
Mouse, Human, Monkey, Pig
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
CD207 Molecule
Introduction
CD207 (CD207 Molecule) is a Protein Coding gene. Diseases associated with CD207 include Birbeck Granule Deficiency and Langerhans Cell Histiocytosis. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and mannose binding.
An important paralog of this gene is CLEC4F.
Entrez Gene ID
Human50489
Mouse246278
Monkey703420
Pig100037935
Rabbit100357377
UniProt ID
HumanQ9UJ71
MouseQ8VBX4
MonkeyA0A2K5TX38
PigB3FVQ1
RabbitG1T8P6
Function
Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.
Biological Process
Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
Defense response to virus Source: UniProtKB
Receptor-mediated endocytosis Source: Reactome
Cellular Location
Membrane. Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.
Involvement in disease
Birbeck granule deficiency (BIRGD): A condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules, Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.
Topology
Cytoplasmic: 1-43
Helical: 44-64
Extracellular: 65-328

Wang, H., Chen, X., Li, S., Zhou, C., Xu, L., Wu, Z., & Chen, X. (2021). Identification and expression analysis of Langerhans cells marker Langerin/CD207 in grass carp, Ctenopharyngodon idella. Gene, 768, 145315.

Wu, B. C., Olivia, N. A., Tembo, J. M., He, Y. X., Zhang, Y. M., Xue, Y., ... & Chen, T. (2021). Loss of the virulence plasmid by Shigella sonnei promotes its interactions with CD207 and CD209 receptors. Journal of Medical Microbiology, 70(3), 001297.

van Dalen, R., Fuchsberger, F. F., Rademacher, C., van Strijp, J. A., & van Sorge, N. M. (2020). A common genetic variation in langerin (CD207) compromises cellular uptake of Staphylococcus aureus. Journal of innate immunity, 12(2), 191-200.

Maarifi, G., Czubala, M. A., Lagisquet, J., Ivory, M. O., Fuchs, K., Papin, L., ... & Blanchet, F. P. (2020). Langerin (CD207) represents a novel interferon-stimulated gene in Langerhans cells. Cellular & molecular immunology, 17(5), 547-549.

Pergolizzi, S., Marino, A., Capillo, G., Aragona, M., Marconi, P., & Lauriano, E. R. (2020). Expression of Langerin/CD 207 and α-smooth muscle actin in ex vivo rabbit corneal keratitis model. Tissue and Cell, 66, 101384.

Lauriano, E. R., Pergolizzi, S., Cascio, P. L., Kuciel, M., Zizzo, N., Guerrera, M. C., ... & Capillo, G. (2020). Expression of Langerin/CD207 in airways, lung and associated lymph nodes of a stranded striped dolphin (Stenella coeruleoalba). Acta histochemica, 122(2), 151471.

van Dalen, R., Jacinto, S., Rumpret, M., Fuchsberger, F. F., van Teijlingen, N. H., Hanske, J., ... & van Sorge, N. M. (2018). Staphylococcus aureus wall teichoic acid is a pathogen-associated molecular pattern that is recognized by langerin (CD207) on skin Langerhans cells. bioRxiv, 238469.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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