CLDN4
The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Sep 2013]
Full Name
Claudin 4
Function
Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Biological Process
Bicellular tight junction assembly Source: GO_Central
Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
Cell adhesion Source: GO_Central
Chloride transport Source: UniProtKB-KW
Circadian rhythm Source: Ensembl
Establishment of skin barrier Source: UniProtKB
Female pregnancy Source: Ensembl
Positive regulation of cell migration Source: ARUK-UCL
Positive regulation of metallopeptidase activity Source: ARUK-UCL
Positive regulation of wound healing Source: ARUK-UCL
Regulation of cell morphogenesis Source: ARUK-UCL
Renal absorption Source: UniProtKB
Response to progesterone Source: Ensembl
Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
Cell adhesion Source: GO_Central
Chloride transport Source: UniProtKB-KW
Circadian rhythm Source: Ensembl
Establishment of skin barrier Source: UniProtKB
Female pregnancy Source: Ensembl
Positive regulation of cell migration Source: ARUK-UCL
Positive regulation of metallopeptidase activity Source: ARUK-UCL
Positive regulation of wound healing Source: ARUK-UCL
Regulation of cell morphogenesis Source: ARUK-UCL
Renal absorption Source: UniProtKB
Response to progesterone Source: Ensembl
Cellular Location
Cell membrane; Tight junction. CLDN4 is required for tight junction localization in the kidney.
Involvement in disease
CLDN4 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.
Topology
Cytoplasmic: 1-7
Helical: 8-28
Extracellular: 29-81
Helical: 82-102
Cytoplasmic: 103-117
Helical: 118-138
Extracellular: 139-160
Helical: 161-181
Cytoplasmic: 182-209
Helical: 8-28
Extracellular: 29-81
Helical: 82-102
Cytoplasmic: 103-117
Helical: 118-138
Extracellular: 139-160
Helical: 161-181
Cytoplasmic: 182-209
PTM
Phosphorylated. Phosphorylation by EPHA2 is stimulated by EFNA1 and alters interaction with TJP1.
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Anti-CLDN4 antibodies
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CompareTarget: CLDN4
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-209
Tag: Flag Tag
Target: CLDN4
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-209
Tag: His & Strep Tag
Target: CLDN4
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-209
Tag: Flag Tag
Target: CLDN4
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 2-209
Tag: His Tag
Target: CLDN4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 10F4
Application*: E, F
Target: CLDN4
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: 8G7
Application*: E
Target: CLDN4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 2G12
Application*: E
Target: CLDN4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBNH-040
Application*: IH, WB, IP
Target: CLDN4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBCNC-190
Application*: N, IP, F
Target: CLDN4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-0459
Application*: F
Target: CLDN4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXC-0943
Application*: F, E
Target: CLDN4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-1156
Application*: IF
Target: CLDN4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYY-C0047
Application*: E, IF, IP, WB, P
Target: CLDN4
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 4A4
Application*: E, WB
Target: CLDN4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Dog, Fish, Human, Mouse, Pig, Rabbit, Rat, Virus
Clone: C1112
Application*: WB, IH, IF, IP
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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