CLEC9A
CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells (Huysamen et al., 2008 [PubMed 18408006]).
Full Name
C-Type Lectin Domain Containing 9A
Alternative Names
C-Type Lectin Domain Containing 9A; C-Type Lectin Domain Family 9 Member A; C-Type Lectin Domain Family 9, Member A; HEEE9341; UNQ9341; DNGR-1; CD370; DNGR1;
Function
Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.
Biological Process
Positive regulation of cytokine production Source: UniProtKB
Receptor-mediated endocytosis Source: UniProtKB
Receptor-mediated endocytosis Source: UniProtKB
Cellular Location
Membrane
Topology
Cytoplasmic: 1-35
Helical: 36-56
Extracellular: 57-241
Helical: 36-56
Extracellular: 57-241
PTM
N-glycosylated.
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Anti-CLEC9A antibodies
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CompareTarget: CLEC9A
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: AG53
Application*: F, IF, WB
Target: CLEC9A
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: C8401
Application*: IH
Target: CLEC9A
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 1F6
Application*: WB, F, IC/IF
Target: CLEC9A
Sensitivity: 0.042 ng/mL
Detection Range: 0.1-40 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: CLEC9A
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 135-264
Tag: His Tag
Target: CLEC9A
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 57-264
Tag: hFc Tag
Target: CLEC9A
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 57-241
Tag: hFc Tag
Target: CLEC9A
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT3255
Application*: F
Target: CLEC9A
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT3496
Application*: IC, F
Target: CLEC9A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-1939
Application*: WB
Target: CLEC9A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYC-1938
Application*: F
Target: CLEC9A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0184
Application*: F
Target: CLEC9A
Host: Rat
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: 7H11
Application*: F, E, IF, IP, WB
Target: CLEC9A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 8F9
Application*: F, IF
Target: CLEC9A
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 397
Application*: WB
Target: CLEC9A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: C7953
Application*: F, I
Target: CLEC9A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Monkey
Clone: C0346
Application*: WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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