CLPS

The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Full Name
Colipase
Function
Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
Biological Process
Lipid catabolic process Source: UniProtKB-KW
Lipid digestion Source: Reactome
Lipid metabolic process Source: ProtInc
Response to bacterium Source: Ensembl
Response to food Source: GO_Central
Retinoid metabolic process Source: Reactome
Cellular Location
Secreted
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Anti-CLPS antibodies

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CLPS Matched Antibody Pair (278) (APMAB-278LY)

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Target: CLPS
Specificity: Human
Datasheet SDS

Mouse Anti-CLPS Recombinant Antibody (4G3) (CBMAB-C6989-LY)

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Target: CLPS
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4G3
Application*: E, WB
Datasheet SDS

Pig CLPS ELISA Kit (V2LY-0626-LY952)

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Target: CLPS
Sensitivity: 5.05 mU/mL
Detection Range: 10-2000 mU/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Pig
Assay Type: Sandwich
Reactivity: Pig
Datasheet SDS

Mouse Clps ELISA Kit (V2LY-0626-LY2200)

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Target: Clps
Sensitivity: 0.024 ng/mL
Detection Range: 0.05-20 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Datasheet SDS

Rat Recombinant CLPS protein, His Tag (V2LY-0526-LY9297)

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Target: CLPS
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-112
Tag: His Tag
Datasheet SDS

Human Recombinant CLPS protein, His Tag (V2LY-0526-LY3244)

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Target: CLPS
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-112
Tag: His Tag
Datasheet SDS

Mouse Anti-CLPS Recombinant Antibody (CBYY-C3241) (V2LY-1206-LY289)

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Target: CLPS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C3241
Application*: E
Datasheet SDS

Mouse Anti-CLPS Recombinant Antibody (CBFYC-1960) (V2LY-1206-LY288)

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Target: CLPS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-1960
Application*: P
Datasheet SDS

Mouse Anti-CLPS Recombinant Antibody (CBFYC-1959) (V2LY-1206-LY287)

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Target: CLPS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1959
Application*: P
Datasheet SDS

Mouse Anti-CLPS Recombinant Antibody (8A8) (V2LY-1206-LY286)

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Target: CLPS
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 8A8
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-CLPS Recombinant Antibody (1G5) (V2LY-1206-LY284)

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Target: CLPS
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1G5
Application*: E
Datasheet SDS

Rabbit Anti-CLPS Recombinant Antibody (111) (V2LY-1206-LY283)

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Target: CLPS
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 111
Application*: E, P
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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