CXADR

CXADR (CXADR, Ig-Like Cell Adhesion Molecule) is a Protein Coding gene. Diseases associated with CXADR include Myocarditis and Dilated Cardiomyopathy. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. Gene Ontology (GO) annotations related to this gene include identical protein binding and integrin binding. An important paralog of this gene is ENSG00000277666.

CXADR, Ig-Like Cell Adhesion Molecule

Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.

(Microbial infection) Acts as a receptor for adenovirus type C.

(Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6.

Actin cytoskeleton reorganization Source: UniProtKB
AV node cell-bundle of His cell adhesion involved in cell communication Source: BHF-UCL
AV node cell to bundle of His cell communication Source: UniProtKB
Cardiac muscle fiber development Source: UniProtKB
Cell-cell junction organization Source: UniProtKB
Defense response to virus Source: UniProtKB
Epithelial structure maintenance Source: UniProtKB
Gamma-delta T cell activation Source: UniProtKB
Germ cell migration Source: UniProtKB
Heart development Source: UniProtKB
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
Homotypic cell-cell adhesion Source: UniProtKB
Leukocyte migration Source: Reactome
Mitochondrion organization Source: UniProtKB
Neutrophil chemotaxis Source: UniProtKB
Regulation of AV node cell action potential Source: BHF-UCL
Regulation of immune response Source: Reactome
Transepithelial transport Source: UniProtKB

Isoform 1: Cell membrane; Basolateral cell membrane; Tight junction; Adherens junction. In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions (PubMed:12297051). In airway epithelial cells localized to basolateral membrane but not to apical surface (PubMed:11316797).
Isoform 3&4&5: Secreted

Extracellular: 20-237
Helical: 238-258
Cytoplasmic: 259-365

N-glycosylated.
Palmitoylated on Cys-259 and/or Cys-260; required for proper localization to the plasma membrane.