CXADR

CXADR (CXADR, Ig-Like Cell Adhesion Molecule) is a Protein Coding gene. Diseases associated with CXADR include Myocarditis and Dilated Cardiomyopathy. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. Gene Ontology (GO) annotations related to this gene include identical protein binding and integrin binding. An important paralog of this gene is ENSG00000277666.

Full Name

CXADR, Ig-Like Cell Adhesion Molecule

Function

Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.

(Microbial infection) Acts as a receptor for adenovirus type C.

(Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6.

Biological Process

Actin cytoskeleton reorganization Source: UniProtKB
AV node cell-bundle of His cell adhesion involved in cell communication Source: BHF-UCL
AV node cell to bundle of His cell communication Source: UniProtKB
Cardiac muscle fiber development Source: UniProtKB
Cell-cell junction organization Source: UniProtKB
Defense response to virus Source: UniProtKB
Epithelial structure maintenance Source: UniProtKB
Gamma-delta T cell activation Source: UniProtKB
Germ cell migration Source: UniProtKB
Heart development Source: UniProtKB
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
Homotypic cell-cell adhesion Source: UniProtKB
Leukocyte migration Source: Reactome
Mitochondrion organization Source: UniProtKB
Neutrophil chemotaxis Source: UniProtKB
Regulation of AV node cell action potential Source: BHF-UCL
Regulation of immune response Source: Reactome
Transepithelial transport Source: UniProtKB

Cellular Location

Isoform 1: Cell membrane; Basolateral cell membrane; Tight junction; Adherens junction. In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions (PubMed:12297051). In airway epithelial cells localized to basolateral membrane but not to apical surface (PubMed:11316797).
Isoform 3&4&5: Secreted

Topology

Extracellular: 20-237
Helical: 238-258
Cytoplasmic: 259-365

PTM

N-glycosylated.
Palmitoylated on Cys-259 and/or Cys-260; required for proper localization to the plasma membrane.