DGAT2

Acyl-CoA:diacylglycerol acyltransferase, or DGAT (EC 2.3.1.20), is responsible for the synthesis of triglycerides. It catalyzes a reaction in which diacylglycerol is covalently joined to long chain fatty acyl-CoAs.[supplied by OMIM

Full Name

diacylglycerol O-acyltransferase homolog 2 (mouse)

Function

Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides (PubMed:27184406).

Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity).

Functions also as an acyl-CoA retinol acyltransferase (ARAT) (By similarity).

Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705).

Biological Process

Acylglycerol acyl-chain remodeling Source: Reactome
Bile acid signaling pathway Source: Ensembl
Cellular response to oleic acid Source: BHF-UCL
Cellular triglyceride homeostasis Source: BHF-UCL
Cholesterol homeostasis Source: BHF-UCL
Diacylglycerol biosynthetic process Source: UniProtKB
Diacylglycerol metabolic process Source: BHF-UCL
Fat pad development Source: BHF-UCL
Fatty acid homeostasis Source: BHF-UCL
Glycerol metabolic process Source: UniProtKB-KW
Lipid metabolic process Source: GO_Central
Lipid storage Source: BHF-UCL
Long-chain fatty-acyl-CoA metabolic process Source: BHF-UCL
Low-density lipoprotein particle clearance Source: BHF-UCL
Monoacylglycerol biosynthetic process Source: UniProtKB
Negative regulation of fatty acid oxidation Source: Ensembl
Positive regulation of gluconeogenesis Source: Ensembl
Positive regulation of triglyceride biosynthetic process Source: Ensembl
Regulation of cholesterol metabolic process Source: Ensembl
Regulation of lipoprotein metabolic process Source: Ensembl
Regulation of plasma lipoprotein particle levels Source: BHF-UCL
Triglyceride biosynthetic process Source: UniProtKB

Cellular Location

Endoplasmic reticulum membrane; Lipid droplet; Perinuclear region

Topology

Cytoplasmic: 1-69
Helical: 70-88
Lumenal: 89-92
Helical: 93-112
Cytoplasmic: 113-388