DRAP1

Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex.
Full Name
DRAP1
Function
The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own.
Biological Process
Negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
Positive regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of transcription, DNA-templated Source: GO_Central
Transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
PTM
Phosphorylation reduces DNA binding, but has no effect on heterodimerization and TBP binding.
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Anti-DRAP1 antibodies

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Mouse Anti-DRAP1 Antibody (1A12) (CBMAB-0310-YC)

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Target: DRAP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1A12
Application*: IP, WB, M
Datasheet SDS

Mouse Anti-DRAP1 Recombinant Antibody (N0718) (V2LY-0425-LY921)

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Target: DRAP1
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human, Mouse, Rat, Horse, Dog, Cattle, Pig
Clone: N0718
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-DRAP1 Monoclonal Antibody (CBWJN-1085) (V2LY-0425-LY920)

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Target: DRAP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CBWJN-1085
Application*: IP, WB
Datasheet SDS

Mouse Anti-DRAP1 Recombinant Antibody (D1671) (V2LY-0425-LY919)

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Target: DRAP1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: D1671
Application*: IF, F
Datasheet SDS

Mouse Anti-DRAP1 Recombinant Antibody (D1670) (V2LY-0425-LY918)

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Target: DRAP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: D1670
Application*: P, IF, F
Datasheet SDS

Mouse Anti-DRAP1 Monoclonal Antibody (1A12) (V2LY-0425-LY917)

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Target: DRAP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: 1A12
Application*: IP, WB
Datasheet SDS

Mouse Anti-DRAP1 Recombinant Antibody (H-3) (CBMAB-N0718-WJ)

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Target: DRAP1
Host: Mouse
Specificity: Human, Mouse, Rat
Clone: H-3
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-DRAP1 Recombinant Antibody (CBWJN-1085) (CBMAB-N0717-WJ)

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Target: DRAP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBWJN-1085
Application*: WB
Datasheet SDS

Mouse Anti-DRAP1 Recombinant Antibody (2A17) (CBMAB-D1671-YC)

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Target: DRAP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2A17
Application*: E, WB
Datasheet SDS

Mouse Anti-DRAP1 Recombinant Antibody (2A16) (CBMAB-D1670-YC)

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Target: DRAP1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2A16
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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