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Mouse Anti-DRAP1 Monoclonal Antibody (1A12) (V2LY-0425-LY917)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
1A12
Antibody Isotype
IgG2b
Application
IP, WB

Basic Information

Immunogen
Recombinant protein.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB0.2-0.5 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Preservative
None
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
DRAP1
Entrez Gene ID
Human10589
Mouse66556
Rat293674
UniProt ID
HumanQ14919
MouseQ9D6N5
RatA0JPP1
Function
The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own.
Biological Process
Negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
Positive regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of transcription, DNA-templated Source: GO_Central
Transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
PTM
Phosphorylation reduces DNA binding, but has no effect on heterodimerization and TBP binding.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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