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Rabbit Anti-DRAP1 Recombinant Antibody (CBWJN-1085) (CBMAB-N0717-WJ)

This product is a Rabbit antibody that recognizes DRAP1. The antibody CBWJN-1085 can be used for immunoassay techniques such as: WB.
See all DRAP1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBWJN-1085
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1.291 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
DRAP1
Introduction
Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human10589
Mouse66556
Rat293674
UniProt ID
HumanQ14919
MouseQ9D6N5
RatA0JPP1
Alternative Names
DR1 Associated Protein 1; Negative Cofactor 2 Alpha; NC2-Alpha; DR1-Associated Corepressor; Dr1-Associated Corepressor; Negative Co-Factor 2-Alpha; Negative Cofactor 2-Alpha; Dr1-Associated Protein 1;
Function
The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own.
Biological Process
Negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
Positive regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of transcription, DNA-templated Source: GO_Central
Transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
PTM
Phosphorylation reduces DNA binding, but has no effect on heterodimerization and TBP binding.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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