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Mouse Anti-DRAP1 Recombinant Antibody (D1670) (V2LY-0425-LY918)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
D1670
Antibody Isotype
IgG2b
Application
IHC-P, IF, FC

Basic Information

Immunogen
Recombinant human DRAP1 protein.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
IF(ICC)1-2 µg/ml
IHC-P1-2 µg/ml
FC1-2 µg/10^6 cells

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
BSA & PBS
Preservative
Sodium Azide
Concentration
0.2 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
DRAP1
Entrez Gene ID
10589
UniProt ID
Q14919
Function
The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own.
Biological Process
Negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
Positive regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of transcription, DNA-templated Source: GO_Central
Transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
PTM
Phosphorylation reduces DNA binding, but has no effect on heterodimerization and TBP binding.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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