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Mouse Anti-DRAP1 Antibody (1A12) (CBMAB-0310-YC)

Provided herein are mouse monoclonal antibodies against Human DRAP1. The antibody clone 1A12 can be used for immunoassay techniques, such as IP, WB and MA.
See all DRAP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1A12
Antibody Isotype
IgG2b
Application
IP, WB, MA

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
DRAP1
Introduction
DRAP1 (DR1 associated protein 1) is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex.
Entrez Gene ID
10589
UniProt ID
Q14919
Alternative Names
DR1 Associated Protein 1; DR1-Associated Protein 1 (Negative Cofactor 2 Alpha); Negative Cofactor 2 Alpha; Negative Cofactor 2-Alpha; NC2-Alpha; DR1-Associated Corepressor; Negative Co-Factor 2-Alpha; Dr1-Associated Protein 1
Function
The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own.
Biological Process
Negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
Positive regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of transcription, DNA-templated Source: GO_Central
Transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
PTM
Phosphorylation reduces DNA binding, but has no effect on heterodimerization and TBP binding.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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