DRD2

This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing.

Dopamine Receptor D2

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (PubMed:21645528).

Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity).

Acid secretion Source: Ensembl
Activation of protein kinase activity Source: Ensembl
Adenohypophysis development Source: BHF-UCL
Adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_Central
Adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: BHF-UCL
Adult walking behavior Source: BHF-UCL
Arachidonic acid secretion Source: BHF-UCL
Associative learning Source: BHF-UCL
Auditory behavior Source: Ensembl
Autophagy Source: Ensembl
Axonogenesis Source: BHF-UCL
Behavioral response to cocaine Source: BHF-UCL
Behavioral response to ethanol Source: BHF-UCL
Branching morphogenesis of a nerve Source: BHF-UCL
Cellular calcium ion homeostasis Source: BHF-UCL
Cerebral cortex GABAergic interneuron migration Source: BHF-UCL
Circadian regulation of gene expression Source: BHF-UCL
Dopamine metabolic process Source: BHF-UCL
Drinking behavior Source: Ensembl
Excitatory postsynaptic potential Source: ParkinsonsUK-UCL
G protein-coupled receptor internalization Source: Ensembl
Grooming behavior Source: Ensembl
Hyaloid vascular plexus regression Source: UniProtKB
Intracellular signal transduction Source: BHF-UCL
Locomotory behavior Source: BHF-UCL
Long-term memory Source: Ensembl
Negative regulation of adenylate cyclase activity Source: BHF-UCL
Negative regulation of blood pressure Source: BHF-UCL
Negative regulation of cell death Source: Ensembl
Negative regulation of cell migration Source: BHF-UCL
Negative regulation of cell population proliferation Source: BHF-UCL
Negative regulation of circadian sleep/wake cycle, sleep Source: Ensembl
Negative regulation of cytosolic calcium ion concentration Source: GO_Central
Negative regulation of dopamine receptor signaling pathway Source: BHF-UCL
Negative regulation of dopamine secretion Source: Ensembl
Negative regulation of innate immune response Source: Ensembl
Negative regulation of insulin secretion Source: Ensembl
Negative regulation of protein kinase B signaling Source: BHF-UCL
Negative regulation of protein phosphorylation Source: Ensembl
Negative regulation of protein secretion Source: BHF-UCL
Negative regulation of synaptic transmission, glutamatergic Source: BHF-UCL
Negative regulation of voltage-gated calcium channel activity Source: BHF-UCL
Nervous system process involved in regulation of systemic arterial blood pressure Source: BHF-UCL
Neuron-neuron synaptic transmission Source: BHF-UCL
Orbitofrontal cortex development Source: Ensembl
Peristalsis Source: BHF-UCL
Phospholipase C-activating dopamine receptor signaling pathway Source: MGI
Pigmentation Source: Ensembl
Positive regulation of cytokinesis Source: UniProtKB
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling Pathway Source: BHF-UCL
Positive regulation of dopamine uptake involved in synaptic transmission Source: BHF-UCL
Positive regulation of ERK1 and ERK2 cascade Source: Ensembl
Positive regulation of glial cell-derived neurotrophic factor production Source: CACAO
Positive regulation of G protein-coupled receptor signaling pathway Source: Ensembl
Positive regulation of growth hormone secretion Source: BHF-UCL
Positive regulation of long-term synaptic potentiation Source: Ensembl
Positive regulation of multicellular organism growth Source: Ensembl
Positive regulation of neuroblast proliferation Source: BHF-UCL
Positive regulation of receptor internalization Source: Ensembl
Positive regulation of renal sodium excretion Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of urine volume Source: Ensembl
Postsynaptic modulation of chemical synaptic transmission Source: Ensembl
Prepulse inhibition Source: BHF-UCL
Protein localization Source: BHF-UCL
Regulation of dopamine secretion Source: GO_Central
Regulation of dopamine uptake involved in synaptic transmission Source: BHF-UCL
Regulation of heart rate Source: BHF-UCL
Regulation of locomotion involved in locomotory behavior Source: Ensembl
Regulation of long-term neuronal synaptic plasticity Source: BHF-UCL
Regulation of phosphoprotein phosphatase activity Source: Ensembl
Regulation of potassium ion transport Source: BHF-UCL
Regulation of sodium ion transport Source: BHF-UCL
Regulation of synapse structural plasticity Source: Ensembl
Regulation of synaptic transmission, GABAergic Source: BHF-UCL
Regulation of synaptic vesicle exocytosis Source: Ensembl
Release of sequestered calcium ion into cytosol Source: BHF-UCL
Response to amphetamine Source: BHF-UCL
Response to axon injury Source: Ensembl
Response to cocaine Source: BHF-UCL
Response to drug Source: BHF-UCL
Response to histamine Source: BHF-UCL
Response to hypoxia Source: Ensembl
Response to inactivity Source: Ensembl
Response to iron ion Source: Ensembl
Response to light stimulus Source: BHF-UCL
Response to morphine Source: BHF-UCL
Response to nicotine Source: Ensembl
Response to toxic substance Source: Ensembl
Sensory perception of smell Source: BHF-UCL
Striatum development Source: Ensembl
Synapse assembly Source: BHF-UCL
Temperature homeostasis Source: BHF-UCL
Visual learning Source: BHF-UCL
Wnt signaling pathway Source: Ensembl

Golgi apparatus membrane; Cell membrane

Extracellular: 1-37
Helical: 38-60
Cytoplasmic: 61-70
Helical: 71-93
Extracellular: 94-108
Helical: 109-130
Cytoplasmic: 131-151
Helical: 152-172
Extracellular: 173-188
Helical: 189-213
Cytoplasmic: 214-373
Helical: 374-395
Extracellular: 396-409
Helical: 410-431
Cytoplasmic: 432-443

Palmitoylated. Palmitoylation which is required for proper localization to the plasma membrane and stability of the receptor could be carried on by ZDHHC4, ZDHHC3 and ZDHHC8.