E2F8

E2F transcription factors, such as E2F8, are essential for orchestrating expression of genes required for cell cycle progression and proliferation (Christensen et al., 2005 [PubMed 16179649]).[supplied by OMIM

E2F8

Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene.

Cell cycle comprising mitosis without cytokinesis Source: UniProtKB
Cell population proliferation Source: Ensembl
Chorionic trophoblast cell differentiation Source: UniProtKB
Hepatocyte differentiation Source: UniProtKB
Negative regulation of cytokinesis Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Placenta development Source: UniProtKB
Positive regulation of DNA endoreduplication Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Sprouting angiogenesis Source: UniProtKB
Trophoblast giant cell differentiation Source: UniProtKB

Nucleus