GAL
Galanin is small neuropeptide that functions as a cellular messenger within the central and peripheral nervous systems, modulating diverse physiologic functions (Mechenthaler, 2008 [PubMed 18500643]).[supplied by OMIM
Full Name
galanin prepropeptide
Function
Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion.
Biological Process
cAMP-mediated signaling Source: UniProtKB
Feeding behavior Source: Ensembl
Inflammatory response Source: Ensembl
Insulin secretion Source: UniProtKB
Negative regulation of lymphocyte proliferation Source: Ensembl
Neuropeptide signaling pathway Source: GO_Central
Positive regulation of apoptotic process Source: Ensembl
Positive regulation of cortisol secretion Source: UniProtKB
Positive regulation of large conductance calcium-activated potassium channel activity Source: UniProtKB
Positive regulation of timing of catagen Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Protein kinase A signaling Source: UniProtKB
Regulation of glucocorticoid metabolic process Source: Ensembl
Response to drug Source: Ensembl
Response to estrogen Source: Ensembl
Response to immobilization stress Source: Ensembl
Response to insulin Source: Ensembl
Feeding behavior Source: Ensembl
Inflammatory response Source: Ensembl
Insulin secretion Source: UniProtKB
Negative regulation of lymphocyte proliferation Source: Ensembl
Neuropeptide signaling pathway Source: GO_Central
Positive regulation of apoptotic process Source: Ensembl
Positive regulation of cortisol secretion Source: UniProtKB
Positive regulation of large conductance calcium-activated potassium channel activity Source: UniProtKB
Positive regulation of timing of catagen Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Protein kinase A signaling Source: UniProtKB
Regulation of glucocorticoid metabolic process Source: Ensembl
Response to drug Source: Ensembl
Response to estrogen Source: Ensembl
Response to immobilization stress Source: Ensembl
Response to insulin Source: Ensembl
Cellular Location
Secreted
Involvement in disease
Epilepsy, familial temporal lobe, 8 (ETL8):
A focal form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lobe. Seizures are usually accompanied by sensory symptoms, most often auditory in nature.
A focal form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lobe. Seizures are usually accompanied by sensory symptoms, most often auditory in nature.
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Anti-GAL antibodies
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Target: GAL
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: 9G360
Application*: E, WB
Target: GAL
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBLG1-500
Application*: WB
Target: GAL
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBLG1-498
Application*: WB
Target: GAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLG1-497
Application*: WB
Target: GAL
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-495
Application*: E, WB
Target: GAL
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBLG1-025
Application*: E, WB
Target: GAL
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 581403
Application*: IH, F
Target: GAL
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-0226
Application*: F
Target: GAL
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: TS106
Application*: F, P
Target: GAL
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-2964
Application*: E, WB
Target: GAL
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBLNG-184
Application*: F, IH
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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