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GALNT6

This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin. [provided by RefSeq, Jul 2008]

Full Name

Polypeptide N-Acetylgalactosaminyltransferase 6

Function

Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. May participate in synthesis of oncofetal fibronectin. Has activity toward Muc1a, Muc2, EA2 and fibronectin peptides.

Biological Process

O-glycan processing Source: Reactome
Protein O-linked glycosylation Source: ProtInc

Cellular Location

Golgi apparatus membrane

Topology

Cytoplasmic: 1-8
Helical: 9-28
Lumenal: 29-622

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Anti-GALNT6 antibodies

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Mouse Anti-GALNT6 Recombinant Antibody (CBLG1-511) (CBMAB-G1867-LY)

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Target: GALNT6

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBLG1-511

Application*: E, EC, WB

Mouse Anti-GALNT6 Recombinant Antibody (CBLG1-509) (CBMAB-G1865-LY)

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Target: GALNT6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLG1-509

Application*: WB

Mouse Anti-GALNT6 Recombinant Antibody (CBLG1-511) (V2LY-1225-LY631)

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Target: GALNT6

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: CBLG1-511

Application*: WB, E, IP

Rabbit Anti-GALNT6 Recombinant Antibody (CBLG1-509) (V2LY-1225-LY630)

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Target: GALNT6

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBLG1-509

Application*: WB, P

Mouse Anti-GALNT6 Recombinant Antibody (CBFYH-0234) (V2LY-1225-LY629)

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Target: GALNT6

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYH-0234

Application*: WB, E

Mouse Anti-GALNT6 (AA 523-623) Recombinant Antibody (CBFYH-0234) (CBMAB-H1104-FY)

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Target: GALNT6

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYH-0234

Application*: E, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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